Tomlinson E, Malspeis L
J Pharm Sci. 1982 Oct;71(10):1121-5. doi: 10.1002/jps.2600711011.
Using liquid scintillation counting and liquid chromatographic techniques, it has been demonstrated that the anthracycline antibiotics, doxorubicin hydrochloride, N-trifluoroacetyladriamycin-14-valerate, and N-trifluoroacetyladriamycin-14-octanoate, can be strongly absorbed to the walls of containers, depending on the nature of both the container material and the solute. It also has been shown that the esters are unstable in the chemical growth media commonly used in cell culture studies. Both the adsorption and stability effects are suggested as being factors which should be carefully considered in interpretation of the in vitro and perhaps in vivo activities of the anthracycline esters.
使用液体闪烁计数法和液相色谱技术已证明，蒽环类抗生素、盐酸多柔比星、N-三氟乙酰阿霉素-14-戊酸酯和N-三氟乙酰阿霉素-14-辛酸酯，可根据容器材料和溶质的性质强烈吸附于容器壁上。还表明这些酯在细胞培养研究中常用的化学生长培养基中不稳定。吸附和稳定性影响均被认为是在解释蒽环类酯的体外活性以及可能的体内活性时应仔细考虑的因素。
