HLA系统与金盐及青霉胺治疗类风湿关节炎的副作用
HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis.
作者信息
Bardin T, Dryll A, Debeyre N, Ryckewaert A, Legrand L, Marcelli A, Dausset J
出版信息
Ann Rheum Dis. 1982 Dec;41(6):599-601. doi: 10.1136/ard.41.6.599.
Abstract
Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlation was observed between gold side effects and the haplotype A1 Cw7 B8 DR3 (p less than 10(-2), RR = 8.0). In addition 3 out of 4 cases of renal intolerance to D-penicillamine were observed in patients possessing the Cw7 B8 DR3 haplotype.
摘要
在67例接受金盐（硫代苹果酸金钠）治疗的类风湿性关节炎患者中，无论金中毒反应的类型如何，均发现其与HLA抗原A1、B8、Cw7和DR3之间存在显著相关性（p<10⁻²）。对42例患者进行了基因分型，观察到金的副作用与单倍型A1 Cw7 B8 DR3之间存在相关性（p<10⁻²，相对危险度=8.0）。此外，在具有Cw7 B8 DR3单倍型的患者中，观察到4例对D-青霉胺有肾不耐受的患者中有3例出现这种情况。
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