Addy M, Rawle L, Handley R, Newman H N, Coventry J F
J Periodontol. 1982 Nov;53(11):693-9. doi: 10.1902/jop.1982.53.11.693.
This study reports on the development of drug containing acrylic strips for delivering antimicrobial agents and compares the in vitro release pattern with dialysis tubing. Polyethylmethacrylic strips of suitable dimensions containing 10 to 50% chlorhexidine acetate, 40% metronidazole and 40% tetracycline were prepared. Daily release of the incorporated drugs into 1 ml aliquots was measured spectrophotometrically over a 14 day period. Similarly the release of chlorhexidine gluconate from various lengths of patent and heat sealed dialysis tubing was recorded for 4 days. At 30%, 40% and 50% admixtures the acrylic strips released chlorhexidine up to the 14 day period and a parallel bioassay confirmed the maintenance of antibacterial activity to this time. At the same admixture the release of metronidazole was greater than chlorhexidine and tetracycline. All drugs were released at high levels on day 1 followed by a marked fall in release by day 2 and progressive fall thereafter. The release from tubing was almost total within 24 hours and was independent of sealing the ends. The strips appear to have potential for prolonged drug delivery to periodontal pockets. Preliminary clinical use revealed no patient acceptability problems and alterations in subgingival flora were produced.
本研究报告了含抗菌剂的丙烯酸条带的研制情况，并将其体外释放模式与透析管进行了比较。制备了含有10%至50%醋酸氯己定、40%甲硝唑和40%四环素的尺寸合适的聚甲基丙烯酸乙酯条带。在14天的时间内，通过分光光度法测定掺入药物每日向1毫升等分试样中的释放量。同样，记录了不同长度的专利热封透析管中葡萄糖酸氯己定4天的释放情况。在30%、40%和50%的混合物中，丙烯酸条带在14天内持续释放氯己定，同时进行的生物测定证实此时抗菌活性得以维持。在相同混合物中，甲硝唑的释放量大于氯己定和四环素。所有药物在第1天释放量很高，随后在第2天显著下降，此后逐渐下降。透析管在24小时内几乎完全释放，且与两端密封无关。这些条带似乎有向牙周袋长期给药的潜力。初步临床应用显示没有患者接受度问题，并且龈下菌群发生了改变。
