乳腺中的细胞类型与形态发生
Cell types and morphogenesis in the mammary gland.
作者信息
Dulbecco R, Henahan M, Armstrong B
出版信息
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7346-50. doi: 10.1073/pnas.79.23.7346.
Abstract
Cell types present in the mammary gland and their evolution were studied by labeling female rats with radioactive thymidine at various phases of the estrus cycle. The results suggest that the stem cells for mammary development are present in the terminal end buds and that they generate a lineage for lumenal cells and possibly a distinct one for myoepithelial cells. Growth and differentiation are controlled by both hormones and local factors.
摘要
通过在发情周期的不同阶段用放射性胸苷标记雌性大鼠，研究了乳腺中存在的细胞类型及其演变。结果表明，乳腺发育的干细胞存在于末端芽中，它们产生了腔上皮细胞的谱系，可能还产生了一个不同的肌上皮细胞谱系。生长和分化受激素和局部因素的控制。
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