O'Brien C P, Terenius L, Wahlström A, McLellan A T, Krivoy W
Ann N Y Acad Sci. 1982;398:377-87. doi: 10.1111/j.1749-6632.1982.tb39509.x.
Endorphin levels were measured in 51 cerebrospinal fluid samples from 27 opioid-dependent or postdependent subjects. Radioreceptor assay showed the endorphin levels to be higher than those found in normal subjects. These high levels were found even while subjects were on methadone maintenance. The duration of opioid dependence was positively correlated with fraction I values. Both fractions tended to be lower during early withdrawal than late withdrawal. In naltrexone-maintained patients, radioreceptor assay showed FII to be greatly elevated, but electrophoresis and HPLC indicated that the elevations were not due to a peptide. Thus, the possibility of unextracted naltrexone metabolites remains at least a partial explanation for this apparent FII elevation.
对27名阿片类药物依赖者或戒断后受试者的51份脑脊液样本进行了内啡肽水平检测。放射受体分析法显示，这些受试者的内啡肽水平高于正常受试者。即使在接受美沙酮维持治疗时，也发现了这些高水平。阿片类药物依赖的持续时间与组分I值呈正相关。在早期戒断期间，两个组分的值往往低于晚期戒断。在接受纳曲酮维持治疗的患者中，放射受体分析法显示组分II大幅升高，但电泳和高效液相色谱法表明，这种升高并非由肽引起。因此，未提取的纳曲酮代谢物至少在一定程度上解释了组分II的这种明显升高。
