Makris G P, Saffar J L
Arch Oral Biol. 1982;27(11):965-9. doi: 10.1016/0003-9969(82)90104-2.
Osteoclast activity in terms of number, nucleus content and position in relation to bone surface features was quantitated during experimental periodontal disease. The increase in total osteoclast population, particularly on periosteal rather than endosteal surfaces, was due mainly to the number of cells in direct contact with the bone surface (on-bone osteoclasts). On-bone cell nuclei per mm of bone surface was constantly significantly greater in experimental animals than in controls. There was a positive linear relationship between the extent of resorbing surface and the nucleus content of the on-bone osteoclasts. Thus, in experimental periodontal disease, increases in the number of on-bone osteoclasts are responsible for the changes in the total number of these cells and disease activity is expressed more accurately by the number of nuclei of on-bone osteoclasts per mm of bone surface.
在实验性牙周病期间，对破骨细胞的数量、核含量以及与骨表面特征相关的位置进行了定量分析。破骨细胞总数的增加，尤其是在骨膜表面而非骨髓腔表面，主要是由于直接与骨表面接触的细胞（骨面破骨细胞）数量增加所致。每毫米骨表面的骨面细胞核数量在实验动物中始终显著高于对照组。吸收表面的范围与骨面破骨细胞的核含量之间存在正线性关系。因此，在实验性牙周病中，骨面破骨细胞数量的增加导致了这些细胞总数的变化，并且疾病活动更准确地由每毫米骨表面骨面破骨细胞的核数量来表示。
