左旋咪唑对人体自然杀伤的调节作用。
Regulation of human natural killing by levamisole.
作者信息
Shau H, Dawson J R
出版信息
Cancer Immunol Immunother. 1982;13(1):24-9. doi: 10.1007/BF00200196.
The effect of levamisole on human natural killing (NK) has been studied. In short-term chromium release assays, levamisole at a concentration of 10(-3) M was inhibitory to NK when present in the assays. Pretreatment of NK effector cells and K562 target cells with levamisole separately indicated that the effect was on effector cell activity and was not due to any change in target cell susceptibility. Inactivation of the effector cells required greater than 4 h pretreatment with levamisole if NK activity was subsequently tested in the absence of the drug. Pretreatment with levamisole for up to 19 h had no effect on the lymphocyte proliferative response to phytohemagglutinin (PHA). NK activity of drug-inactivated effector cells recovered after further incubation in levamisole-free medium. Levamisole at 10(-4) M or less had no effect on NK either by pretreatment or by its presence in the NK assays.
已对左旋咪唑对人自然杀伤（NK）的作用进行了研究。在短期铬释放试验中，当试验中存在浓度为10⁻³M的左旋咪唑时，它对NK具有抑制作用。分别用左旋咪唑对NK效应细胞和K562靶细胞进行预处理表明，该作用是对效应细胞活性的影响，而非由于靶细胞敏感性的任何变化。如果随后在无该药物的情况下测试NK活性，效应细胞的失活需要用左旋咪唑预处理超过4小时。用左旋咪唑预处理长达19小时对淋巴细胞对植物血凝素（PHA）的增殖反应没有影响。在无左旋咪唑的培养基中进一步孵育后，药物失活的效应细胞的NK活性得以恢复。10⁻⁴M或更低浓度的左旋咪唑，无论是通过预处理还是在NK试验中存在，对NK均无影响。
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