Son K, Kew M, Rabson A R
Cancer. 1982 Dec 15;50(12):2820-5. doi: 10.1002/1097-0142(19821215)50:12<2820::aid-cncr2820501222>3.0.co;2-#.
Enriched lymphocytes from patients with primary hepatocellular carcinoma showed considerably reduced natural cytotoxicity against two established hepatoma cell lines and against the myelogenous derived cell line K562, as compared to lymphocytes from normal volunteers or from patients with various nonmalignant liver diseases. The serum of hepatoma patients did not effect normal or patient NK cell activity. When lymphocytes from patients or controls were treated for three hours with human leukocyte interferon, NK cell cell activity was significantly improved. Levamisole did not produce a significant increase in normal NK cytotoxicity but did improve the killing of lymphocytes from patients with hepatocellular carcinoma.
与正常志愿者或患有各种非恶性肝脏疾病患者的淋巴细胞相比，原发性肝细胞癌患者的富集淋巴细胞对两种已建立的肝癌细胞系以及对骨髓源性细胞系K562的天然细胞毒性显著降低。肝癌患者的血清不影响正常或患者的自然杀伤细胞（NK）活性。当来自患者或对照的淋巴细胞用人白细胞干扰素处理3小时后，NK细胞活性显著提高。左旋咪唑未使正常NK细胞毒性显著增加，但确实提高了肝细胞癌患者淋巴细胞的杀伤能力。
