尼日利亚菌素预处理的中国仓鼠卵巢细胞中蓖麻毒素内化作用增强。
Enhanced internalization of ricin in nigericin-pretreated Chinese hamster ovary cells.
作者信息
Ray B, Wu H C
机构信息
Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014.
出版信息
Mol Cell Biol. 1981 Jun;1(6):560-7. doi: 10.1128/mcb.1.6.560-567.1981.
Biochemical and electron microscopic autoradiographic studies with [125I] ricin have revealed that nigericin-pretreated Chinese hamster ovary cells are more efficient than untreated cells in the internalization of the toxin into the cells. These results suggest that the enhanced rate of internalization of ricin in nigericin-pretreated cells may account for the enhancement of cytotoxicity of ricin in Chinese hamster ovary cells by nigericin.
用[125I]蓖麻毒素进行的生化和电子显微镜放射自显影研究表明，用尼日利亚菌素预处理的中国仓鼠卵巢细胞在将毒素内化到细胞中的效率比未处理的细胞更高。这些结果表明，尼日利亚菌素预处理的细胞中蓖麻毒素内化速率的提高可能是尼日利亚菌素增强蓖麻毒素对中国仓鼠卵巢细胞细胞毒性的原因。
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