Bennink J R, Doherty P C
J Exp Med. 1980 Jan 1;151(1):166-73. doi: 10.1084/jem.151.1.166.
Immunologically naive BALB/c (H-2d) and C57BL/6J (B6) (H-2b) T-cell populations can, after filtration to remove alloreactive precursor lymphocytes, be induced to respond to vaccinia virus presented in the context of H-2Kk when stimulated in an appropriate recipient. Exposure to vaccinia virus 6 wk previously completely abrogated the capacity of BALB/c T cells to interact with H-2Kk-vaccinia virus. This is also true for negatively selected B6 thoracic duct lymphocytes taken at 14 or 18 d, but not at 6 wk after immunization: the discrepancy is thought to reflect the progressive emergence of new T cells in the latter group. No evidence could be found for the operation of suppression, and the results are considered to indicate that T cells that interact with virus in the absence of the relevant H-2 antigen are tolerized. Whereas stimulation to effector function is H-2 restricted, induction of immune paralysis may be unrestricted. The capacity of T-cell populations to respond to virus presented in the context of allogeneic H-2 determinants thus depends upon previous antigenic experience.
免疫未致敏的BALB/c（H-2d）和C57BL/6J（B6）（H-2b）T细胞群体，在经过过滤以去除同种异体反应性前体淋巴细胞后，当在合适的受体中受到刺激时，能够被诱导对在H-2Kk背景下呈现的痘苗病毒产生反应。6周前接触痘苗病毒完全消除了BALB/c T细胞与H-2Kk - 痘苗病毒相互作用的能力。对于在免疫后14天或18天采集的阴性选择的B6胸导管淋巴细胞也是如此，但在免疫6周后采集的则不然：这种差异被认为反映了后一组中新T细胞的逐渐出现。未发现抑制作用的证据，结果被认为表明在缺乏相关H-2抗原的情况下与病毒相互作用的T细胞被耐受。虽然对效应功能的刺激是H-2限制性的，但免疫麻痹的诱导可能是不受限制的。因此，T细胞群体对在同种异体H-2决定簇背景下呈现的病毒产生反应的能力取决于先前的抗原经历。
