特异性去除同种异体反应潜能的T细胞群体无法被诱导裂解H-2不同的病毒感染靶细胞。
T-cell populations specifically depleted of alloreactive potential cannot be induced to lyse H-2-different virus-infected target cells.
作者信息
Bennink J R, Doherty P C
出版信息
J Exp Med. 1978 Jul 1;148(1):128-35. doi: 10.1084/jem.148.1.128.
Abstract
Mouse lymphocyte populations of one parental H-2 type (A) were specificially depleted of alloreactive potential by filtration through irradiated A X B F1 recipients, and thoracic duct cells were then stimulated with virus in an A X B F1 environment. Experiments using T cells that had previously been exposed to influenza virus in the context of A established that cross-priming for recognition of viral components expressed on H-2-different (B) target cells does not occur. Furthermore, immunologically naive T cells stimulated with vaccinia virus, subsequent to negative selection for reactivity to B, could not be shown to interact with virus-infected cells of type B. Either there is no significant T-cell repertoire for recognition of virus associated with an H-2 determinant not encountered during ontogeny, or such T cells are also alloreactive and are removed during filtration.
摘要
一种亲本H-2类型（A）的小鼠淋巴细胞群体通过经照射的A×B F1受体过滤而特异性地消除了同种异体反应潜能，然后在A×B F1环境中用病毒刺激胸导管细胞。使用先前在A背景下接触过流感病毒的T细胞进行的实验表明，不会发生对在H-2不同（B）靶细胞上表达的病毒成分识别的交叉致敏。此外，在用痘苗病毒刺激后，对B无反应性进行阴性选择的免疫未成熟T细胞，未显示出与B型病毒感染细胞相互作用。要么不存在用于识别在个体发育过程中未遇到的与H-2决定簇相关的病毒的重要T细胞库，要么此类T细胞也是同种异体反应性的，并在过滤过程中被清除。
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T-cell populations specifically depleted of alloreactive potential cannot be induced to lyse H-2-different virus-infected target cells.特异性去除同种异体反应潜能的T细胞群体无法被诱导裂解H-2不同的病毒感染靶细胞。
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引用本文的文献
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2
Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.胸腺移植嵌合体中对非胸腺亲本H-2单倍型特异的T细胞的抑制
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3
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本文引用的文献
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The somatic generation of immune recognition.免疫识别的体细胞产生
Eur J Immunol. 1971 Jan;1(1):1-9. doi: 10.1002/eji.1830010102.
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Disquisitions of Original Antigenic Sin. I. Evidence in man.原始抗原罪的研究。一、人类证据。
J Exp Med. 1966 Sep 1;124(3):331-45. doi: 10.1084/jem.124.3.331.
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Future influenza vaccines and the use of genetic recombinants.未来的流感疫苗与基因重组体的应用。
Bull World Health Organ. 1969;41(3):643-5.
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Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.利用在细胞毒性试验中不发生交叉反应的H-2同基因细胞对次要组织相容性抗原进行二次细胞毒性反应的交叉呈递。
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Cytotoxic T cells recognize male antigen and H-2 as distinct entities.细胞毒性T细胞将雄性抗原和H-2识别为不同的实体。
J Exp Med. 1978 Apr 1;147(4):1291-5. doi: 10.1084/jem.147.4.1291.
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The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.触发病毒加自身特异性细胞毒性T细胞中的淋巴网状系统：T辅助的证据。
J Exp Med. 1978 Mar 1;147(3):897-911. doi: 10.1084/jem.147.3.897.
7
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
J Exp Med. 1978 Mar 1;147(3):882-96. doi: 10.1084/jem.147.3.882.
8
Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A-strain specificity while infected cells confer cross-reactive cytotoxicity.针对甲型流感病毒的细胞毒性T细胞；病毒血凝素诱导甲型毒株特异性，而受感染细胞赋予交叉反应性细胞毒性。
Eur J Immunol. 1977 Sep;7(9):630-5. doi: 10.1002/eji.1830070910.
9
In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells.在辐射嵌合体中，宿主H-2抗原决定供体细胞毒性细胞的免疫反应性。
Nature. 1977 Sep 29;269(5627):417-8. doi: 10.1038/269417a0.
10
Hemagglutinin-specific cytotoxic T-cell response during influenza infection.流感感染期间血凝素特异性细胞毒性T细胞反应。
J Exp Med. 1977 Sep 1;146(3):893-8. doi: 10.1084/jem.146.3.893.
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