体外二次抗体应答中巨噬细胞-淋巴细胞相互作用的H-2基因复合体调控
Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.
作者信息
Pierce C W, Kapp J A, Benacerraf B
出版信息
J Exp Med. 1976 Aug 1;144(2):371-81. doi: 10.1084/jem.144.2.371.
Abstract
The ability of antigen-bearing syngeneic and allogeneic peptone-induced peritoneal exudate macrophages to support development of primary and secondary antibody responses by murine lymphoid or spleen cells in vitro has been investigated. The antigen used was the terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). Syngeneic and allogeneic macrophages supported development of comparable primary antibody responses to GAT, indicating that genetic restrictions do not limit efficient macrophage-lymphocyte interactions in primary responses. By contrast, immunized spleen or lymphoid cells developed secondary antibody responses preferentially when stimulated in vitro with GAT on macrophages syngeneic to the macrophages used to present GAT during in vivo immunization. Thus, genetic restrictions regulate efficient macrophage-lymphocyte interactions in secondary antibody responses. These restrictions have been demonstrated from 2 to 8 wk after a single immunization with limiting quantities of GAT and are controlled by the H-2 gene complex. The implications that immune lymphocytes selectively recognize and respond to antigen presented in the context of the macrophage membrane-antigen complex which sensitized the lymphocytes initially are considered.
摘要
对携带抗原的同基因和异基因蛋白胨诱导的腹腔渗出巨噬细胞在体外支持小鼠淋巴细胞或脾细胞产生初次和二次抗体反应的能力进行了研究。所用抗原为L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的三元共聚物。同基因和异基因巨噬细胞对GAT产生的初次抗体反应相当，这表明基因限制并不限制初次反应中有效的巨噬细胞-淋巴细胞相互作用。相比之下，当用在体内免疫期间用于呈递GAT的巨噬细胞的同基因巨噬细胞上的GAT在体外刺激时，免疫的脾细胞或淋巴细胞优先产生二次抗体反应。因此，基因限制调节二次抗体反应中有效的巨噬细胞-淋巴细胞相互作用。这些限制在单次用限量GAT免疫后的2至8周内得到证实，并受H-2基因复合体控制。考虑到免疫淋巴细胞选择性识别并对最初使淋巴细胞致敏的巨噬细胞膜-抗原复合物背景下呈递的抗原作出反应的含义。
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Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.体外二次抗体应答中巨噬细胞-淋巴细胞相互作用的H-2基因复合体调控
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1
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J Exp Med. 1970 Jan 1;131(1):57-76. doi: 10.1084/jem.131.1.57.
2
The requirement for macrophages in the in vitro immune response.体外免疫反应中对巨噬细胞的需求。
Cell Immunol. 1971 Oct;2(5):399-410. doi: 10.1016/0008-8749(71)90051-7.
3
Cell components in the immune response. II. Cell attachment separation of immune cells.免疫反应中的细胞成分。II. 免疫细胞的细胞附着分离
Cell Immunol. 1970 Jul;1(2):182-9. doi: 10.1016/0008-8749(70)90005-5.
4
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J Exp Med. 1971 Aug 1;134(2):395-416. doi: 10.1084/jem.134.2.395.
5
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J Exp Med. 1974 Oct 1;140(4):921-38. doi: 10.1084/jem.140.4.921.
6
Immune responses in vitro. X. Functions of macrophages.体外免疫反应。X. 巨噬细胞的功能。
J Immunol. 1974 Mar;112(3):1181-9.
7
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8
9
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