Gerosa M A, Amadori G, Semenzato P, Gasparotto G, Carteri A
Childs Brain. 1980;6(2):92-102. doi: 10.1159/000119890.
The authors report their experience on the immunological monitoring of children with posterior fossa medulloblastomas. The most important findings concerning humoral and cell-mediated immunity in this kind of patient are discussed. Among the main immunobiological pictures, the authors stress the remarkable failure of the T-cell dependent immune response, generally correlated to the degree of malignancy of the tumor, and the characteristic appearance of cells with natural cytotoxic activity, whose precise outlining is, at present, in progress. The B-cell dependent pool, mostly investigated through immunofluorescence studies, turned out to be very close to normal.
作者报告了他们对后颅窝髓母细胞瘤患儿进行免疫监测的经验。讨论了这类患者在体液免疫和细胞介导免疫方面的最重要发现。在主要的免疫生物学表现中，作者强调了T细胞依赖性免疫反应的显著缺陷，这通常与肿瘤的恶性程度相关，以及具有自然细胞毒性活性的细胞的特征性表现，目前对其精确描述仍在进行中。主要通过免疫荧光研究调查的B细胞依赖性库结果显示非常接近正常。
