无胸腺小鼠的B细胞库多样性
B cell repertoire diversity in athymic mice.
作者信息
Cancro M P, Klinman N R
出版信息
J Exp Med. 1980 Mar 1;151(3):761-6. doi: 10.1084/jem.151.3.761.
Abstract
The extent of B cell repertoire diversity among nu/nu BALB/c mice has been assessed and compared with that of normal BALB/c mice. This was accomplished through the characterization of monoclonal, influenza hemagglutinin-specific antibodies by reactivity pattern analysis. The results indicate that the repertoire of athymic mice is equivalent in diversity to that of normal mice. Moreover, because these responses were obtained in recipients that were histocompatible but distinct at immunoglobulin allotype loci, these findings indicate that a very diverse array of B cell clonotypes may be stimulated in the absence of allotype-identical T cells.
摘要
已评估无胸腺裸鼠（nu/nu BALB/c小鼠）中B细胞库的多样性程度，并与正常BALB/c小鼠的进行比较。这是通过反应模式分析对单克隆流感血凝素特异性抗体进行表征来实现的。结果表明，无胸腺小鼠的细胞库在多样性上与正常小鼠相当。此外，由于这些反应是在组织相容性相同但免疫球蛋白同种异型位点不同的受体中获得的，这些发现表明，在没有同种异型相同的T细胞的情况下，可能会刺激非常多样的B细胞克隆型。
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