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1
B cell repertoire diversity in athymic mice.无胸腺小鼠的B细胞库多样性
J Exp Med. 1980 Mar 1;151(3):761-6. doi: 10.1084/jem.151.3.761.
2
Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.抗体库的模式化获得：新生BALB/c小鼠中血凝素特异性B细胞库的多样性
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3
The diversity of the influenza-specific primary B-cell repertoire in BALB/c mice.BALB/c小鼠中流感特异性初始B细胞库的多样性。
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4
Immunological properties of athymic nude mice born from homozygous (nu/nu) parents.由纯合子（nu/nu）亲本所生的无胸腺裸鼠的免疫学特性。
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Adoptive transfer of allotype-specific suppressor cells inhibits thymus-independent immunoglobulin production in syngeneic athymic mice.同种异型特异性抑制细胞的过继转移可抑制同基因无胸腺小鼠中不依赖胸腺的免疫球蛋白产生。
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7
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8
Interleukin 2 is mitogenic for nu/nu and nu/+ murine spleen cells.白细胞介素2对无胸腺裸鼠（nu/nu）和杂合子小鼠（nu/+）的脾细胞具有促有丝分裂作用。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2398-402. doi: 10.1073/pnas.78.4.2398.
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Autoimmune syndrome after induction of neonatal tolerance to alloantigens. CD4+ T cells from the tolerant host activate autoreactive F1 B cells.新生儿对同种异体抗原诱导耐受后的自身免疫综合征。来自耐受宿主的CD4+ T细胞激活自身反应性F1 B细胞。
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IgG subclass, IgE, and IgA anti-trinitrophenyl antibody production within trinitrophenyl-Ficoll-responsive B cell clones. Evidence in support of three distinct switching pathways.三硝基苯 - 聚蔗糖应答性B细胞克隆内IgG亚类、IgE和IgA抗三硝基苯抗体的产生。支持三种不同转换途径的证据。
J Exp Med. 1983 Jan 1;157(1):69-85. doi: 10.1084/jem.157.1.69.

引用本文的文献

1
Control of B cell differentiation by T cells.T细胞对B细胞分化的调控。
Surv Immunol Res. 1983;2(3):216-9. doi: 10.1007/BF02918415.
2
Developmental aspects of B-cell repertoire phenotype.B细胞库表型的发育方面
Surv Immunol Res. 1983;2(1):62-77. doi: 10.1007/BF02918397.

本文引用的文献

1
Precursor cells specific to sheep red cells in nude mice. Estimation of frequency in the microculture system.裸鼠中绵羊红细胞特异性前体细胞。微培养系统中频率的估计。
Eur J Immunol. 1973 Jul;3(7):392-7. doi: 10.1002/eji.1830030704.
2
Towards a network theory of the immune system.迈向免疫系统的网络理论。
Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89.
3
Antibody responses to antigenic determinants of influenza virus hemagglutinin. I. Thymus dependence of antibody formation and thymus independence of immunological memory.针对流感病毒血凝素抗原决定簇的抗体反应。I. 抗体形成的胸腺依赖性及免疫记忆的胸腺非依赖性
J Exp Med. 1974 Dec 1;140(6):1559-70. doi: 10.1084/jem.140.6.1559.
4
Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.新生和成年小鼠脾细胞对体外诱导B细胞耐受性的差异敏感性。
J Exp Med. 1976 Jul 1;144(1):293-7. doi: 10.1084/jem.144.1.293.
5
The diversity of the influenza-specific primary B-cell repertoire in BALB/c mice.BALB/c小鼠中流感特异性初始B细胞库的多样性。
J Exp Med. 1978 Mar 1;147(3):776-87. doi: 10.1084/jem.147.3.776.
6
Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype.决定轻链可变区免疫球蛋白遗传标记的基因座上的分离影响独特型表达的遗传。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4600-4. doi: 10.1073/pnas.74.10.4600.
7
Cell fractionation methods and the target cells for clonal abortion of B lymphocytes.细胞分级分离方法及B淋巴细胞克隆流产的靶细胞
Immunol Rev. 1979;43:184-216. doi: 10.1111/j.1600-065x.1979.tb00422.x.
8
Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.抗体库的模式化获得：新生BALB/c小鼠中血凝素特异性B细胞库的多样性
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6577-81. doi: 10.1073/pnas.76.12.6577.
9
Individual antigen-specific T lymphocytes: helper function in enabling the expression of multiple antibody isotypes.单个抗原特异性T淋巴细胞：在多种抗体同种型表达中发挥辅助功能。
J Exp Med. 1978 Sep 1;148(3):759-65. doi: 10.1084/jem.148.3.759.
10
Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.细胞毒性T细胞在胸腺分化过程中学习对自身H-2的特异性。
Nature. 1978 Jan 19;271(5642):251-3. doi: 10.1038/271251a0.

无胸腺小鼠的B细胞库多样性

B cell repertoire diversity in athymic mice.

作者信息

Cancro M P, Klinman N R

出版信息

J Exp Med. 1980 Mar 1;151(3):761-6. doi: 10.1084/jem.151.3.761.

DOI:10.1084/jem.151.3.761
PMID:6965704
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185795/
Abstract

The extent of B cell repertoire diversity among nu/nu BALB/c mice has been assessed and compared with that of normal BALB/c mice. This was accomplished through the characterization of monoclonal, influenza hemagglutinin-specific antibodies by reactivity pattern analysis. The results indicate that the repertoire of athymic mice is equivalent in diversity to that of normal mice. Moreover, because these responses were obtained in recipients that were histocompatible but distinct at immunoglobulin allotype loci, these findings indicate that a very diverse array of B cell clonotypes may be stimulated in the absence of allotype-identical T cells.

摘要

已评估无胸腺裸鼠（nu/nu BALB/c小鼠）中B细胞库的多样性程度，并与正常BALB/c小鼠的进行比较。这是通过反应模式分析对单克隆流感血凝素特异性抗体进行表征来实现的。结果表明，无胸腺小鼠的细胞库在多样性上与正常小鼠相当。此外，由于这些反应是在组织相容性相同但免疫球蛋白同种异型位点不同的受体中获得的，这些发现表明，在没有同种异型相同的T细胞的情况下，可能会刺激非常多样的B细胞克隆型。