• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.新生和成年小鼠脾细胞对体外诱导B细胞耐受性的差异敏感性。
J Exp Med. 1976 Jul 1;144(1):293-7. doi: 10.1084/jem.144.1.293.
2
B cell tolerance. I. Analysis of hapten-specific unresponsiveness induced in vitro in adult and neonatal murine spleen cell populations.B细胞耐受性。I. 对成年和新生小鼠脾细胞群体体外诱导的半抗原特异性无反应性的分析。
J Immunol. 1977 Dec;119(6):2054-9.
3
Ontogeny of susceptibility of mouse splenic B cells to tolerance induction in vitro by TNP-D-GL.小鼠脾脏B细胞体外对TNP-D-GL诱导耐受敏感性的个体发生
Eur J Immunol. 1979 Jan;9(1):76-80. doi: 10.1002/eji.1830090116.
4
The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. V. IgD-bearing cells in immunological tolerance.小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。V. 免疫耐受中的IgD阳性细胞
Eur J Immunol. 1982 Oct;12(10):838-44. doi: 10.1002/eji.1830121008.
5
Autoimmune syndrome after induction of neonatal tolerance to alloantigens: effects of in vivo treatment with anti-T cell subset monoclonal antibodies.诱导新生儿对同种异体抗原产生耐受性后的自身免疫综合征：抗T细胞亚群单克隆抗体体内治疗的效果
J Immunol. 1987 Sep 1;139(5):1426-31.
6
In vitro tolerance induction of primed, IgD-negative murine spleen cells.致敏的、IgD 阴性小鼠脾细胞的体外耐受诱导
J Exp Med. 1981 Mar 1;153(3):653-64. doi: 10.1084/jem.153.3.653.
7
Immunoglobulin receptors on murine B lymphocytes.小鼠B淋巴细胞上的免疫球蛋白受体。
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:185-91. doi: 10.1101/sqb.1977.041.01.024.
8
Characterization of cytotoxic cells in mice rendered neonatally tolerant of MHC alloantigens: evidence for repertoire modification.新生期对MHC同种异体抗原耐受的小鼠中细胞毒性细胞的特征：免疫库修饰的证据
J Immunol. 1987 Jun 1;138(11):3661-8.
9
The induction of hapten-specific immunological tolerance and immunity in B lymphocytes. VI. Differential tolerance susceptibility in adult spleen as a function of B-cell maturation level.B淋巴细胞中半抗原特异性免疫耐受与免疫的诱导。VI. 成年脾脏中不同的耐受易感性与B细胞成熟水平的关系。
J Exp Med. 1979 Sep 19;150(3):491-506. doi: 10.1084/jem.150.3.491.
10
B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells.B细胞耐受性。IV. 表面IgM和IgD在决定小鼠B细胞耐受性易感性中的不同作用。
J Exp Med. 1977 Dec 1;146(6):1804-8. doi: 10.1084/jem.146.6.1804.

引用本文的文献

1
Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice.高亲和力胰岛素反应性 B 淋巴细胞的失能沉默及其对 NOD 遗传背景下小鼠的影响。
Diabetologia. 2018 Dec;61(12):2621-2632. doi: 10.1007/s00125-018-4730-z. Epub 2018 Sep 25.
2
Immunosenescence and immune response in organ transplantation.器官移植中的免疫衰老与免疫反应
Int Rev Immunol. 2014 May-Jun;33(3):162-73. doi: 10.3109/08830185.2013.829469. Epub 2013 Oct 15.
3
Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.表达 IgD 超抗原的转基因小鼠外周 B 细胞耐受和功能。
J Immunol. 2010 Apr 15;184(8):4143-58. doi: 10.4049/jimmunol.0903564. Epub 2010 Mar 15.
4
Establishing anergy as a bona fide in vivo mechanism of B cell tolerance.确立无反应性作为B细胞耐受性的一种真正的体内机制。
J Immunol. 2009 Nov 1;183(9):5439-41. doi: 10.4049/jimmunol.0990088.
5
Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes.脾酪氨酸激酶（Syk）的激活对于B淋巴细胞的下游信号转导而言并不充分。
BMC Immunol. 2002 Dec 6;3:16. doi: 10.1186/1471-2172-3-16.
6
Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.成熟和未成熟B细胞中独特抗原受体相关基因表达程序的不同信号阈值。
J Exp Med. 1999 Sep 20;190(6):749-56. doi: 10.1084/jem.190.6.749.
7
Two new proteins preferentially associated with membrane immunoglobulin D.两种新的蛋白质优先与膜免疫球蛋白D相关联。
EMBO J. 1994 Aug 15;13(16):3793-800. doi: 10.1002/j.1460-2075.1994.tb06690.x.
8
B cell repertoire diversity in athymic mice.无胸腺小鼠的B细胞库多样性
J Exp Med. 1980 Mar 1;151(3):761-6. doi: 10.1084/jem.151.3.761.
9
Genetic and temporal control of neonatal antibody expression.新生儿抗体表达的遗传与时间控制。
J Exp Med. 1983 Apr 1;157(4):1170-83. doi: 10.1084/jem.157.4.1170.
10
The use of immunological tolerance to investigate B lymphocyte replacement kinetics in chickens.利用免疫耐受研究鸡体内B淋巴细胞替代动力学。
J Math Biol. 1983;16(2):131-40. doi: 10.1007/BF00276053.

本文引用的文献

1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
3
An in vitro primary immune response to 2,4,6-trinitrophenyl substituted erythrocytes: response against carrier and hapten.对2,4,6-三硝基苯基取代红细胞的体外初次免疫反应：针对载体和半抗原的反应。
J Immunol. 1970 Jun;104(6):1558-61.
4
In vitro induction of specific unresponsiveness against the 2,4,6-trinitrophenyl determinant. I. The induction of unresponsiveness.体外诱导对2,4,6-三硝基苯基决定簇的特异性无反应性。I. 无反应性的诱导
J Immunol. 1974 Mar;112(3):1139-48.
5
Characterization of splenic lymphoid cells in fetal and newborn mice.胎儿和新生小鼠脾脏淋巴细胞的特征分析
J Exp Med. 1973 Sep 1;138(3):557-73. doi: 10.1084/jem.138.3.557.
6
Differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice.小鼠体内对异种红细胞反应中前体细胞的差异刺激及载体特异性胸腺来源细胞活性
J Immunol. 1972 Jan;108(1):54-8.
7
Ontogeny of B lymphocytes. II. Relative rates of appearance of lymphocytes bearing surface immunoglobulin and complement receptors.B淋巴细胞的个体发生。II. 带有表面免疫球蛋白和补体受体的淋巴细胞的相对出现率。
J Exp Med. 1974 May 1;139(5):1125-41. doi: 10.1084/jem.139.5.1125.
8
Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells.脑相关θ抗原：兔抗小鼠脑与小鼠淋巴细胞的反应性。
Cell Immunol. 1971 Aug;2(4):353-61. doi: 10.1016/0008-8749(71)90070-0.
9
Neonatal tolerance induced by antibody against antigen-specific receptor.由抗抗原特异性受体抗体诱导的新生儿耐受性。
Science. 1974 Nov 15;186(4164):640-3. doi: 10.1126/science.186.4164.640.
10
T and B cell in hapten-specific carrier-determined tolerance.半抗原特异性载体决定的耐受性中的T细胞和B细胞
J Exp Med. 1975 Nov 1;142(5):1254-62. doi: 10.1084/jem.142.5.1254.

新生和成年小鼠脾细胞对体外诱导B细胞耐受性的差异敏感性。

Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.

作者信息

Cambier J C, Kettman J R, Vitetta E S, Uhr J W

出版信息

J Exp Med. 1976 Jul 1;144(1):293-7. doi: 10.1084/jem.144.1.293.

DOI:10.1084/jem.144.1.293
PMID:1084409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190369/
Abstract

The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C' and the helper T cells with anti-Ly-2.2 and C'. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.

摘要

在体外研究了新生和成年小鼠脾细胞对诱导B细胞耐受性的相对敏感性。与9至12日龄新生小鼠的细胞相比，成年细胞诱导产生耐受性所需的三硝基苯基 - 人γ球蛋白大约多1000倍。通过用抗Thy-1和补体C'预处理培养的B细胞以及用抗Ly-2.2和补体C'预处理辅助性T细胞，排除了抑制性T细胞的潜在影响。讨论了细胞表面免疫球蛋白同种型在导致这种观察到的差异中可能发挥的作用。