新生和成年小鼠脾细胞对体外诱导B细胞耐受性的差异敏感性。
Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.
作者信息
Cambier J C, Kettman J R, Vitetta E S, Uhr J W
出版信息
J Exp Med. 1976 Jul 1;144(1):293-7. doi: 10.1084/jem.144.1.293.
Abstract
The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C' and the helper T cells with anti-Ly-2.2 and C'. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.
摘要
在体外研究了新生和成年小鼠脾细胞对诱导B细胞耐受性的相对敏感性。与9至12日龄新生小鼠的细胞相比，成年细胞诱导产生耐受性所需的三硝基苯基 - 人γ球蛋白大约多1000倍。通过用抗Thy-1和补体C'预处理培养的B细胞以及用抗Ly-2.2和补体C'预处理辅助性T细胞，排除了抑制性T细胞的潜在影响。讨论了细胞表面免疫球蛋白同种型在导致这种观察到的差异中可能发挥的作用。
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