Lehman T J, Hanson V, Singsen B H, Kornreich H K, Bernstein B, King K
J Pediatr. 1980 Apr;96(4):657-61. doi: 10.1016/s0022-3476(80)80733-5.
The specificity of antibodies directed against dsDNA for SLE in a childhood population was tested by analyzing sera from 62 children with lupus and 283 children with other known or suspected autoimmune diseases. The role of these antibodies in the manifestations of SLE was then examined by correlating dsDNA Ab titer with clinical manifestations in 311 sera from 20 children followed for a mean of 51 months. Antibodies to dsDNA were found to be highly specific for SLE. The presence of antibodies in titers of 1:80 or greater correlated with the presence of active disease, arthritis, and rash, but not with azotemia, proteinuria, or increasing proteinuria; this indicated that their role in the induction of lupus nephritis was different from that in the induction of rash and arthritis. This may be due to a requirement for small immune complex formation during times of antigen excess in the initiation of lupus nephritis.
通过分析62名狼疮患儿和283名患有其他已知或疑似自身免疫性疾病患儿的血清，对儿童群体中抗双链DNA抗体对系统性红斑狼疮（SLE）的特异性进行了检测。随后，通过将双链DNA抗体滴度与20名患儿的311份血清中的临床表现进行关联分析，研究了这些抗体在SLE表现中的作用，这些患儿平均随访了51个月。发现抗双链DNA抗体对SLE具有高度特异性。滴度为1:80或更高的抗体的存在与活动性疾病、关节炎和皮疹的存在相关，但与氮质血症、蛋白尿或蛋白尿增加无关；这表明它们在狼疮性肾炎诱导中的作用与在皮疹和关节炎诱导中的作用不同。这可能是由于在狼疮性肾炎起始阶段抗原过量时形成小免疫复合物的需求所致。
