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人工器官的新旧方面及修订内容。

Old, new and revised aspects of artificial organs.

作者信息

Kolff W J

出版信息

Int J Artif Organs. 1980 Mar;3(2):94-102.

PMID:6965927
Abstract

Retrograde perfusion of the coronary veins with oxygenated blood is effective. Closed chest transarterial left ventricular bypass was developed by Hans Zwart to support the failing left ventricle. Transapical left ventricular bypass started by Alex Kralios, later studied by Jeffrey Peters et al, became effective when filters were introduced into the system--first surviving patient! One must be prepared to support both ventricles. Retrograde transpulmonary bypass (Kralios) is as yet only experimental. The blood is pumped from one occluded pulmonary artery into the aorta. Plasmapheresis removes particles with a molecular weight of 7 to 45,000 which may be harmful in patients with burns or oxygenators since they blind the leukocytes. Starling's Law will regulate the total artificial heart. The future is for the electrohydraulic artificial heart by Robert Jarvik. However, air driven hearts may offer a life of sufficient quality to people now doomed to die. All types of hemodialyzers or peritoneal dialyzers should be made portable or wearable. The "mouse" is a good peritoneal access device. It makes recirculating peritoneal dialysis practical.

摘要

用含氧血液逆行灌注冠状静脉是有效的。汉斯·兹瓦特研发了闭式经动脉左心室旁路术来支持衰竭的左心室。亚历克斯·克拉利奥斯开创的经心尖左心室旁路术,后来由杰弗里·彼得斯等人进行研究,当在系统中引入过滤器后变得有效——首例存活患者!必须做好支持双心室的准备。逆行经肺旁路术(克拉利奥斯)目前仍仅处于实验阶段。血液从一条阻塞的肺动脉被泵入主动脉。血浆置换可去除分子量为7至45000的颗粒,这些颗粒在烧伤患者或氧合器中可能有害,因为它们会使白细胞失活。斯塔林定律将调节全人工心脏。未来属于罗伯特·贾维克的电动液压人工心脏。然而,气动心脏可能会为现在注定死亡的人提供有足够质量的生活。所有类型的血液透析器或腹膜透析器都应制成便携式或可穿戴式。“小鼠”是一种很好的腹膜通路装置。它使循环腹膜透析成为可能。

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