用半抗原修饰的淋巴细胞诱导对1-氟-2,4-二硝基苯接触敏感性的耐受性。II. 在F1小鼠中对识别与亲本主要组织相容性复合体抗原相关的1-氟-2,4-二硝基苯的T细胞亚群的选择性耐受性。
Induction of tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity with hapten-modified lymphoid cells. II. Selective tolerance in F1 mice of T cell subsets recognizing 1-fluoro-2,4-dinitrobenzene associated with parental major histocompatibility complex antigens.
作者信息
Conlon P J, Moorhead J W, Miller S D, Claman H N
出版信息
J Exp Med. 1980 Apr 1;151(4):959-64. doi: 10.1084/jem.151.4.959.
Abstract
F1 animals were tolerized to 1-fluoro-2,4-dinitrobenzene (DNFB) contact sensitivity with parentally derived, in vitro hapten-modified spleen cells. This tolerant state was found, upon adoptive transfer to naive parental strain recipients, to affect only that T cell subpopulation that recognized the parental haplotype of the cell used as the tolerogen, and did not inhibit the ability of the remaining T cell subset to confer immunity. This demonstrates that this tolerant state involves the inactivation of a cell required for the expression of contact sensitivity by recognizing DNFB in association with self major histocompatibility complex gene products.
摘要
用亲代来源的、体外经半抗原修饰的脾细胞使F1代动物对1-氟-2,4-二硝基苯（DNFB）接触敏感性产生耐受。当将这种耐受状态过继转移给未接触过的亲代品系受体时，发现它仅影响识别用作耐受原的细胞的亲代单倍型的T细胞亚群，而不抑制其余T细胞亚群赋予免疫的能力。这表明这种耐受状态涉及通过识别与自身主要组织相容性复合体基因产物相关联的DNFB来使接触敏感性表达所需的细胞失活。
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Induction of tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity with hapten-modified lymphoid cells. II. Selective tolerance in F1 mice of T cell subsets recognizing 1-fluoro-2,4-dinitrobenzene associated with parental major histocompatibility complex antigens.用半抗原修饰的淋巴细胞诱导对1-氟-2,4-二硝基苯接触敏感性的耐受性。II. 在F1小鼠中对识别与亲本主要组织相容性复合体抗原相关的1-氟-2,4-二硝基苯的T细胞亚群的选择性耐受性。
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Genetic restrictions for the induction of suppressor T cells by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity. Role of the H-2D region of the major histocompatibility complex.在对1-氟-2,4-二硝基苯接触敏感性的耐受性中，半抗原修饰的淋巴细胞诱导抑制性T细胞的遗传限制。主要组织相容性复合体H-2D区域的作用。
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H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization.半抗原修饰的淋巴细胞在对1-氟-2,4-二硝基苯接触致敏的耐受性中诱导抑制性T细胞的H-2限制
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The induction of tolerance to DNFB contact sensitivity using hapten modified lymphoid cells. I. Cellular requirements for rapid induction of tolerance.使用半抗原修饰的淋巴细胞诱导对二硝基氟苯接触敏感性的耐受性。I. 快速诱导耐受性的细胞要求。
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Efficient induction of immediate tolerance to contact sensitivity by hapten-modified spleen cells requires Ia+ cells compatible with recipient.通过半抗原修饰的脾细胞高效诱导对接触敏感性的即时耐受需要与受体相容的Ia +细胞。
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Lack of oral tolerance but oral priming for contact sensitivity to dinitrofluorobenzene in major histocompatibility complex class II-deficient mice and in CD4+ T cell-depleted mice.在主要组织相容性复合体II类缺陷小鼠和CD4+ T细胞耗竭小鼠中，缺乏口服耐受性，但对二硝基氟苯的接触敏感性存在口服致敏作用。
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Influence of contact sensitivity to DNFB on the induction of carrier-determined tolerance to DNP.对二硝基氟苯的接触敏感性对诱导载体决定的对二硝基苯基耐受性的影响。
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本文引用的文献
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Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。II. 来自同种异体供体品系的T淋巴细胞和B淋巴细胞在对半抗原-蛋白质结合物的体液反应中缺乏生理性协同相互作用。
J Exp Med. 1973 Jun 1;137(6):1405-18. doi: 10.1084/jem.137.6.1405.
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H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.H-2基因复合体限制小鼠迟发型超敏反应的转移。
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5095-8. doi: 10.1073/pnas.72.12.5095.
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Efficient induction of immediate tolerance to contact sensitivity by hapten-modified spleen cells requires Ia+ cells compatible with recipient.通过半抗原修饰的脾细胞高效诱导对接触敏感性的即时耐受需要与受体相容的Ia +细胞。
Nature. 1979 Mar 15;278(5701):257-9. doi: 10.1038/278257a0.
5
Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. II. Evidence for restrictions affecting helper cell induction and T-B collaboration, both mapping to the K-end of the H-2 complex.在经辐照的亲代品系小鼠中对异源红细胞进行阳性选择的F1杂种T细胞的受限辅助功能。II. 影响辅助细胞诱导和T-B协作的限制证据，二者均定位于H-2复合体的K端。
J Exp Med. 1978 Apr 1;147(4):1159-74. doi: 10.1084/jem.147.4.1159.
6
Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. I. Failure to collaborate with B cells of the opposite parental strain not associated with active suppression.在经辐照的亲代品系小鼠中对异源红细胞呈阳性选择的F1杂种T细胞的受限辅助功能。I. 未能与不伴有主动抑制的相反亲代品系的B细胞协作。
J Exp Med. 1978 Apr 1;147(4):1142-58. doi: 10.1084/jem.147.4.1142.
7
A splenic requirement for the generation of suppressor T cells.生成抑制性T细胞对脾脏的需求。
J Immunol. 1977 Dec;119(6):2095-9.
8
Tolerance: two pathways of negative immunoregulation in contact sensitivity to DNFB.
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:105-11. doi: 10.1101/sqb.1977.041.01.014.
9
The induction of hapten-specific T cell tolerance using hapten-modified lymphoid membranes. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state.使用半抗原修饰的淋巴细胞膜诱导半抗原特异性T细胞耐受。II. 抑制性T细胞和克隆抑制在耐受状态中的相对作用。
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10
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