半抗原修饰的淋巴细胞在对1-氟-2,4-二硝基苯接触致敏的耐受性中诱导抑制性T细胞的H-2限制
H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization.
作者信息
Miller S D, Sy M S, Claman H N
出版信息
J Exp Med. 1977 Apr 1;145(4):1071-6. doi: 10.1084/jem.145.4.1071.
Abstract
Studies using hapten-modified lymphoid cells as tolerogens for 1-fluoro-2,4-dinitrobenzene contact sensitization have shown that BALB/c(H-2d) mice can be made phenotypically tolerant by dinitrophenyl (DNP) on either syngeneic or allogeneic mouse lymphoid cells (DNP-LC). However, suppressor T-cell induction (Ts) in these mice (as demonstrated by adoptive transfer to syngeneic recipients) was restricted to H-2 identity between the DNP-LC and the donor mouse. It was also shown that identity at the right end of the H-2 complex was sufficient for Ts induction. In addition, this restriction was also demostrated in CBA (H-2 K) mice and for tolerance in the 1-chloro-2,4,6-trinitrobenzene contact sensitivity system using trinitrophenyl-modified lymphoid cells.
摘要
使用经半抗原修饰的淋巴细胞作为1-氟-2,4-二硝基苯接触致敏的耐受原的研究表明，BALB/c（H-2d）小鼠可通过二硝基苯基（DNP）修饰的同基因或异基因小鼠淋巴细胞（DNP-LC）产生表型耐受。然而，这些小鼠中的抑制性T细胞诱导（Ts）（通过过继转移至同基因受体证明）仅限于DNP-LC与供体小鼠之间的H-2同一性。还表明，H-2复合体右端的同一性足以诱导Ts。此外，在CBA（H-2K）小鼠以及使用三硝基苯基修饰的淋巴细胞的1-氯-2,4,6-三硝基苯接触敏感性系统的耐受中也证明了这种限制。
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H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization.半抗原修饰的淋巴细胞在对1-氟-2,4-二硝基苯接触致敏的耐受性中诱导抑制性T细胞的H-2限制
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Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten.非抗原性与免疫耐受性：载体在诱导对半抗原的耐受性中的作用。
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