Saiki O, Negoro S, Tsuyuguchi I, Yamamura Y
Infect Immun. 1980 Apr;28(1):127-31. doi: 10.1128/iai.28.1.127-131.1980.
Persistent diabetes mellitus with marked hyperglycemia was induced in mice by the administration of streptozotocin. In these streptozotocin-induced diabetic mice, resistance to tubercle bacillus challenge and primary as well as secondardy humoral immune responses against foreign erythrocytes were markedly depressed. The T-cell function in delayed hypersensitivity to 2,4-dinitro-1-fluorobenzene and bacterial phagocytic activity or peritoneal macrophages were markedly depressed. In contrast, the B-cell function in antibody production against T-independent antigen and the intracellular killing of bacteria in peritoneal macrophages were intact. We concluded that depression of the T-cell function or the phagocytic activity of macrophages or both may be the main immunological defect in these mice.
通过给予链脲佐菌素在小鼠中诱导出持续性糖尿病伴显著高血糖。在这些链脲佐菌素诱导的糖尿病小鼠中，对结核杆菌攻击的抵抗力以及针对外来红细胞的初次和二次体液免疫反应均明显受到抑制。对2,4 -二硝基-1 -氟苯的迟发型超敏反应中的T细胞功能以及腹膜巨噬细胞的细菌吞噬活性均明显受到抑制。相比之下，针对非T细胞依赖性抗原的抗体产生中的B细胞功能以及腹膜巨噬细胞内的细菌杀伤功能是完整的。我们得出结论，T细胞功能或巨噬细胞吞噬活性或两者的抑制可能是这些小鼠主要的免疫缺陷。
