Elliott S C, Kleinberg F, Smith T F, Ellefson R D, Herrmann K L
Am J Clin Pathol. 1978 Aug;70(2):234-8. doi: 10.1093/ajcp/70.2.234.
Two neonates, one with extrahepatic biliary atresia and one with cystic fibrosis, and a 9-year-old child with atresia of the common bile duct had conjugated hyperbilirubinemia and elevated rubella HAI titers when kaolin pretreatment of serum was used. A beta-lipoprotein fraction of the serum that is frequently found in association with biliary obstruction was shown to be the probable source of the rubella HAI inhibitor. This beta-lipoprotein was not removed by standard kaolin treatment of serum, but was removed almost completely by dextran sulfate--calcium chloride treatment. In the presence of conjugated hyperbilirubinemia, routine kaolin pretreatment of serum is an inadequate measure for the removal of interfering substances, as false-positive rubella HAI results are obtained consistently.
两名新生儿，一名患有肝外胆道闭锁，另一名患有囊性纤维化，还有一名9岁儿童患有胆总管闭锁，当对血清进行高岭土预处理时，他们均出现结合胆红素血症且风疹血凝抑制（HAI）滴度升高。血清中一种常与胆道梗阻相关的β-脂蛋白部分被证明可能是风疹HAI抑制剂的来源。这种β-脂蛋白不能通过血清的标准高岭土处理去除，但几乎可被硫酸葡聚糖 - 氯化钙处理完全去除。在存在结合胆红素血症的情况下，血清的常规高岭土预处理是去除干扰物质的不充分措施，因为会持续获得风疹HAI假阳性结果。
