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[利用血凝抑制试验和补体结合试验评估免疫状态及诊断近期风疹感染]

[The use of hemagglutination inhibition tests and complement fixation tests for evaluation of immunity states and diagnosis of recent rubella infections].

作者信息

Măgureanu E, Grobnicu M, Botez D

出版信息

Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1975 Jul-Sep;20(3):183-6.

PMID:128107
Abstract

Comparative HAI and CF study of German measles antibodies in 575 sera collected from subjects of different age gave positive HAI reactions in 87% of the cases and positive CF reactions in 55% of the cases. The greater sensitivity of HAI and the longer presence of these antibodies justifies the use of this test for investigating the state of immunity in German measles. The combined use of the two tests for the diagnosis of the disease is very useful especially when the first serum sample is collected some time after the onset when the increase in serum antibody titers can only be demonstrated by CF, as HAI antibodies reach a high titer soon after the onset.

摘要

对从不同年龄受试者采集的575份血清进行的风疹抗体血凝抑制试验(HAI)和补体结合试验(CF)的比较研究显示,87%的病例HAI反应呈阳性,55%的病例CF反应呈阳性。HAI的更高敏感性以及这些抗体的更长存在时间证明了使用该试验来调查风疹免疫状态的合理性。将这两种试验联合用于疾病诊断非常有用,尤其是在发病后一段时间采集第一份血清样本时,此时血清抗体滴度的升高只能通过CF检测出来,因为HAI抗体在发病后很快就会达到高滴度。

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