甲氨蝶呤和羟基脲对中性粒细胞趋化性的影响。

Br J Dermatol. 1980 May;102(5):557-63. doi: 10.1111/j.1365-2133.1980.tb07655.x.

Methotrexate depresses motility of neutrophils in chamber membranes, but does not interfere with random motility in tubes. Hydroxyurea has no such effect. The therapeutic response to methotrexate in psoriasis may be due in part to a reduction in migration of neutrophils into the epidermis.

甲氨蝶呤可抑制中性粒细胞在小室膜中的运动，但不干扰其在试管中的随机运动。羟基脲则无此作用。银屑病对甲氨蝶呤的治疗反应可能部分归因于中性粒细胞向表皮迁移的减少。