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[应激暴露对造血系统反应中T淋巴细胞和B淋巴细胞作用的影响]

[Effect of exposure to stress on the role of T- and B-lymphocytes in the response of the hematopoietic system].

作者信息

Gorizontov P D, Fedotova M I, Belousova O I, Khaitov R M, Chermeneva L I

出版信息

Biull Eksp Biol Med. 1980 Apr;89(4):415-7.

PMID:6966945
Abstract

Cellular composition of the bone marrow, spleen and peripheral blood was studied after 6-hour immobilization on the back in experiments on 4 groups of (CBAxC57BL)F1 mice with varying degree of T lymphocyte deficiency (thymectomy, sham thymectomy, administration of antilymphocytic serum, B mice). The evidence obtained shows that the "lymphoid peak" recorded in the bone marrow during stress is likely to be formed at the expense of T and B lymphocyte migration from the peripheral lymphoid organs. The data have been also obtained, indicating that T lymphocytes migrating to the bone marrow during the first 6-9 hours after the exposure to stress may participate in granulocytopoiesis activation.

摘要

在对4组不同程度T淋巴细胞缺乏(胸腺切除术、假胸腺切除术、给予抗淋巴细胞血清、B小鼠)的(CBAxC57BL)F1小鼠进行背部固定6小时的实验后,研究了骨髓、脾脏和外周血的细胞组成。获得的证据表明,应激期间骨髓中记录到的“淋巴细胞峰”可能是以T和B淋巴细胞从外周淋巴器官迁移为代价形成的。还获得了数据,表明在应激暴露后的最初6 - 9小时内迁移到骨髓的T淋巴细胞可能参与粒细胞生成的激活。

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