Bencze K, Sabatke L, Fruhmann G
Chest. 1980 Jun;77(6):761-3. doi: 10.1378/chest.77.6.761.
In a comparative study, we examined 324 sera of the PiMM phenotype by isoelectric focusing. Sera were obtained from 254 healthy individuals, and from 70 patients suffering from chronic obstructive pulmonary disease (COPD). All individuals were examined, a detailed history and chest x-ray films were taken, and lung function tests were performed. The classification into PiMM subtypes according to a modified method, originally described by Genz et al, showed a significantly higher number of subtypes, containing more slowly migrating protein fractions (M2) in the group of patients. Since the prevalence of bronchitic symptoms is unusually common in industry, in workers who are exposed to dust and smoke tobacco, these findings are important, especially in regard to prophylactic measures in industry.
在一项对比研究中，我们通过等电聚焦分析了324份PiMM表型的血清样本。血清取自254名健康个体以及70名慢性阻塞性肺疾病（COPD）患者。对所有个体进行了检查，记录了详细病史并拍摄了胸部X光片，还进行了肺功能测试。根据最初由根茨等人描述的改良方法对PiMM亚型进行分类，结果显示患者组中含有迁移速度较慢的蛋白质组分（M2）的亚型数量显著更多。由于在工业领域，尤其是接触粉尘和烟草烟雾的工人中，支气管炎症状的患病率异常普遍，因此这些发现具有重要意义，特别是对于工业中的预防措施而言。
