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AKR/J小鼠中θ阳性白血病细胞上的免疫球蛋白表达。

Immunoglobulin expression on theta-positive leukemic cells in AKR/J mice.

作者信息

Pachmann K, Thierfelder S

出版信息

Blut. 1980 Jul;41(1):19-28. doi: 10.1007/BF01039873.

DOI:10.1007/BF01039873
PMID:6967748
Abstract

The expression of surface immunoglobulin was studied on cells of theta-positive AKR leukemia during repeated weekly passages of ascitic cells. It could be shown that the percentage of Ig-positive cells varied considerably (0-25%) and that this was accompanied by variations in the expression of theta-antigen on the cell surface. This was interpreted as repression and derepression of genes coding for surface antigen possibly at the translational level.

摘要

在腹水细胞每周重复传代过程中,对θ阳性AKR白血病细胞的表面免疫球蛋白表达进行了研究。结果表明,Ig阳性细胞的百分比差异很大(0-25%),并且这伴随着细胞表面θ抗原表达的变化。这被解释为可能在翻译水平上对编码表面抗原的基因进行抑制和去抑制。

相似文献

1
Immunoglobulin expression on theta-positive leukemic cells in AKR/J mice.AKR/J小鼠中θ阳性白血病细胞上的免疫球蛋白表达。
Blut. 1980 Jul;41(1):19-28. doi: 10.1007/BF01039873.
2
Functional heterogeneity of murine lymphoid cells. V. Lymphocytes lacking detectable surface theta or immunoglobulin determinants.小鼠淋巴细胞的功能异质性。V. 缺乏可检测到的表面θ或免疫球蛋白决定簇的淋巴细胞。
J Exp Med. 1973 Jul 1;138(1):71-88. doi: 10.1084/jem.138.1.71.
3
In vivo effects of rabbit anti-mouse brain serum on theta bearing lymphocytes of AKR mice.兔抗小鼠脑血清对AKR小鼠含θ淋巴细胞的体内作用。
Immunology. 1975 Apr;28(4):659-68.
4
Lymphocyte surface receptors and leukemia virus-induced immunosuppression.淋巴细胞表面受体与白血病病毒诱导的免疫抑制
Am J Clin Pathol. 1975 May;63(5):735-47. doi: 10.1093/ajcp/63.5.735.
5
Blocking and redistribution ("capping") of antigen receptors on T and B lymphocytes by anti-immunoglobulin antibody.抗免疫球蛋白抗体对T和B淋巴细胞上抗原受体的封闭与再分布(“帽化”)
J Exp Med. 1973 Apr 1;137(4):1060-77. doi: 10.1084/jem.137.4.1060.
6
Potential leukemic cells among bone marrow cells of young AKR/J mice.年轻AKR/J小鼠骨髓细胞中的潜在白血病细胞。
Proc Natl Acad Sci U S A. 1980 May;77(5):2923-6. doi: 10.1073/pnas.77.5.2923.
7
Direct demonstration of theta-positive antigen-binding cells, with antigen-induced movement of thymus-dependent cell receptors.直接证实θ阳性抗原结合细胞,以及抗原诱导的胸腺依赖性细胞受体的移动。
J Exp Med. 1973 Jan 1;137(1):69-84. doi: 10.1084/jem.137.1.69.
8
Thymus-derived (T) cell immunoglobulins. Presence of a receptor site for IgG and absence of large amounts of "buried" Ig determinants on T cells.胸腺来源的(T)细胞免疫球蛋白。T细胞上存在IgG受体位点,且不存在大量“隐蔽”的Ig决定簇。
J Exp Med. 1972 Nov 1;136(5):1323-8. doi: 10.1084/jem.136.5.1323.
9
In vivo phenotypic characteristics of AKR T-cell lymphomas with different leukemic potential: possible role of alpha 4 beta 7 integrin in the progression towards the leukemic phenotype.具有不同白血病潜能的AKR T细胞淋巴瘤的体内表型特征:α4β7整合素在向白血病表型进展中的可能作用。
Int J Cancer. 1994 Feb 15;56(4):560-7. doi: 10.1002/ijc.2910560416.
10
Expression of antigens coded in murine leukemia viruses on thymocytes of allogeneic donor origin in AKR mice following syngeneic or allogeneic bone marrow transplantation.同基因或异基因骨髓移植后,AKR小鼠中源自异基因供体的胸腺细胞上鼠白血病病毒编码抗原的表达。
Cancer Res. 1985 Dec;45(12 Pt 1):6428-35.

本文引用的文献

1
Membrane associated immunoglobulin in pig thymocytes.猪胸腺细胞中的膜相关免疫球蛋白。
Biochem Biophys Res Commun. 1974 Nov 27;61(2):432-40. doi: 10.1016/0006-291x(74)90975-9.
2
Synthesis, transport, dynamics and fate of cell surface Ig and alloantigens in murine lymphocytes.小鼠淋巴细胞中细胞表面免疫球蛋白和同种异体抗原的合成、运输、动态变化及命运
Transplant Rev. 1973;14:50-75. doi: 10.1111/j.1600-065x.1973.tb00102.x.
3
The role of RNA in the immunological deficiency of plasmacytoma.RNA在浆细胞瘤免疫缺陷中的作用。
Ann N Y Acad Sci. 1973 May 31;207:468-80. doi: 10.1111/j.1749-6632.1973.tb47509.x.
4
Biochemical and biological characteristics of lymphocyte surface immunoglobulin.淋巴细胞表面免疫球蛋白的生化与生物学特性
Transplant Rev. 1973;14:3-49. doi: 10.1111/j.1600-065x.1973.tb00101.x.
5
Characterization of two plasmacytoma fractions and their RNA capable of changing lymphocyte surface immunoglobulins (cell conversion).两种浆细胞瘤组分及其能够改变淋巴细胞表面免疫球蛋白的RNA的特性(细胞转化)
Cell Immunol. 1975 Jul;18(1):98-109. doi: 10.1016/0008-8749(75)90040-4.
6
Factors influencing the isolation of membrane immunoglobulins from T and B lymphocytes. 1. Detergent effects and iodination conditions.
J Immunol. 1976 Mar;116(3):847-53.
7
Spontaneous AKR lymphoma with T and B-cell characteristics.具有T细胞和B细胞特征的自发性AKR淋巴瘤。
Nature. 1975 Sep 25;257(5524):314-6. doi: 10.1038/257314a0.
8
Simultaneous quantitation of two antigens in mixture in individual cells by microimmunofluorimetry.通过微量免疫荧光法对单个细胞中混合物中的两种抗原进行同步定量分析。
J Immunol Methods. 1976;12(1-2):67-79. doi: 10.1016/0022-1759(76)90097-1.
9
Murine thymic lymphomas as model tumors for T-cell studies. T-cell markers, immunoglobulin and Fc-receptors on AKR thymomas.作为T细胞研究模型肿瘤的小鼠胸腺淋巴瘤。AKR胸腺瘤上的T细胞标志物、免疫球蛋白和Fc受体。
Cell Immunol. 1976 Jan;21(1):97-111. doi: 10.1016/0008-8749(76)90331-2.
10
Synthesis and characterization of membrane immunoglobulin, Ia, and H-2 molecules of thy 1+ AKR/J lymphomas.thy1+ AKR/J淋巴瘤的膜免疫球蛋白、Ia和H-2分子的合成与表征
J Immunol. 1977 Nov;119(5):1706-10.