Ferrarini M, Cadoni A, Franzi A T, Ghigliotti C, Leprini A, Zicca A, Grossi C E
Eur J Immunol. 1980 Jul;10(7):562-70. doi: 10.1002/eji.1830100714.
The ultrastructural and cytochemical features of human peripheral blood TG cells (T cells with receptors IgG) and of the cells of the so-called third population (non-T, non-B cells with high avidity receptors for IgG) have been investigated and compared. Both TG and third-population cells (TPC) contained acid hydrolases with a paranuclear localization of alpha-naphthyl acid esterase, beta-glucuronidase or acid phosphatase. At the electron microscopy level, TG and TPC were indistinguishable and displayed rough cell surface, indented nuclei, abundant cytoplasm with predominance of the smooth over the rough membranes and peroxidase-negative granules. A large proportion of cells of the TPC could form rosettes with sheep erythrocytes after treatment with neuraminidase. The observed close similarities between TG and TPC may suggest that both cell types belong to a special subset of T cells. However, the alternative hypothesis that both TG and TPC are part of a subset unrelated to T cells, such as a new non-T, non-B cell population, or even of the monocytic-macrophage lineage, is also discussed.
对人外周血TG细胞（带有IgG受体的T细胞）和所谓第三群细胞（对IgG具有高亲和力受体的非T、非B细胞）的超微结构和细胞化学特征进行了研究和比较。TG细胞和第三群细胞（TPC）均含有酸性水解酶，α-萘基酸酯酶、β-葡萄糖醛酸酶或酸性磷酸酶定位于核旁。在电子显微镜水平上，TG细胞和TPC无法区分，均表现为细胞表面粗糙、核凹陷、细胞质丰富，光滑膜多于粗糙膜，且过氧化物酶阴性颗粒。用神经氨酸酶处理后，很大一部分TPC细胞可与绵羊红细胞形成玫瑰花结。观察到的TG细胞和TPC之间的密切相似性可能表明这两种细胞类型都属于T细胞的一个特殊亚群。然而，也讨论了另一种假设，即TG细胞和TPC都是与T细胞无关的亚群的一部分，例如一个新的非T、非B细胞群体，甚至是单核细胞-巨噬细胞谱系的一部分。
