Jobe A, Mannino F, Gluck L
Am J Obstet Gynecol. 1978 Sep 1;132(1):53-8. doi: 10.1016/0002-9378(78)90798-6.
Radioactive palmitic acid, choline, and phosphate were given to rabbits 28 and 30 days pregnant and the labeling;of phosphatidylcholine in the fetal lung and alveolar wash was studied. Labeled phosphatidylcholine was detected initially in the alveolar wash three hours after isotope administration. The three-hour delay was independent of precursor studied or gestational age, and the radioactive phosphatidylcholine continued to accumulate in the wash fluid for at least 18 hours. Each labeled precursor of phosphatidylcholine sequentially labeled the phosphatidylcholine from microsomal, lamellar body and alveolar wash lung fractions of the 30 day fetal animals.
给怀孕28天和30天的兔子注射放射性棕榈酸、胆碱和磷酸盐，并研究胎儿肺和肺泡灌洗液中磷脂酰胆碱的标记情况。同位素给药三小时后，在肺泡灌洗液中首次检测到标记的磷脂酰胆碱。这三小时的延迟与所研究的前体或胎龄无关，放射性磷脂酰胆碱在灌洗液中至少持续积累18小时。磷脂酰胆碱的每种标记前体依次标记30天龄胎儿动物肺微粒体、板层小体和肺泡灌洗部分中的磷脂酰胆碱。
