Engel W K, Hawley R J
J Neurol. 1977 Jun 13;215(3):161-8. doi: 10.1007/BF00312474.
Lesions in skeletal muscle resulting from ischemia caused by peripheral vascular disease in two patients were essentially identical to the early muscle lesions of Duchenne muscular dystrophy (DMD) patients and carriers of that disease, as well as to the early muscle lesions of experimental animals with aorta ligations plus a small dose of 5-hydroxytryptamine (serotonin). The one similarity is harmonious with, although does not necessarily advance, the ischemia hypothesis of DMD, and the other supports the ischemia mechanism proposed in the animal model.
两名因外周血管疾病导致局部缺血而出现骨骼肌损伤的患者，其损伤情况与杜氏肌营养不良症（DMD）患者及其携带者的早期肌肉损伤基本相同，也与接受主动脉结扎并注射小剂量5-羟色胺（血清素）的实验动物的早期肌肉损伤相同。前一种相似性与DMD的局部缺血假说相符，尽管不一定能支持该假说，而后一种相似性则支持了动物模型中提出的局部缺血机制。
