鼠抗独特型抗体引发的大鼠肥大细胞脱颗粒。
Rat mast cell degranulation triggered by murine anti-idiotypic antibodies.
作者信息
Nakagawa T, Blaser K, de Weck A L
出版信息
Int Arch Allergy Appl Immunol. 1980;63(4):462-6. doi: 10.1159/000232663.
PMID:6968720
Abstract
Triggering of rat mast cell degranulation by murine anti-idiotypic antibodies (anti-Id) was investigated, using rat passive cutaneous anaphylactic (PCA) reactions as the method of evaluation. It was shown that the interaction between isologous murine anti-Id directed against anti-benzylpenicilloyl (BPO) antibodies and BPO-specific IgE molecules on the cell surface can induce PCA reactions on rats. The mechanism of cell activation by anti-Id was briefly discussed.
摘要
利用大鼠被动皮肤过敏反应（PCA）作为评估方法，研究了鼠抗独特型抗体（抗Id）对大鼠肥大细胞脱颗粒的触发作用。结果表明，针对抗苄青霉素酰基（BPO）抗体的同种鼠抗Id与细胞表面的BPO特异性IgE分子之间的相互作用可诱导大鼠产生PCA反应。对抗Id激活细胞的机制进行了简要讨论。
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