轻度镇痛药罕见副作用的流行病学评估。
Epidemiological evaluation of rare side-effects of mild analgesics.
作者信息
Levy M
出版信息
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):395S-399S. doi: 10.1111/j.1365-2125.1980.tb01829.x.
Abstract
1 Major adverse reactions to mild analgesics, unless these drugs are abused or taken in high doses, are believed to be rare. 2 However, because of the massive and universal use of these drugs, quantitative measurement of the risk involved is imperative. At present, contradictory regulatory decisions about the use of mild analgesics are based on circumstantial evidence. 3 It is only by the conduct of epidemiological studies that data leading to decisions based on scientifically sound judgments may be obtained.
摘要
- 除非滥用或大剂量服用，一般认为轻度镇痛药的严重不良反应很少见。2. 然而，由于这些药物的广泛大量使用，对其所涉风险进行定量评估势在必行。目前，关于轻度镇痛药使用的监管决策相互矛盾，依据的都是间接证据。3. 只有通过开展流行病学研究，才能获得能让决策基于科学合理判断的数据。
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本文引用的文献
1
Agranulocytosis caused by amidopyrine; an avoidable cause of death.
Br Med J. 1952 Jun 14;1(4771):1270-3. doi: 10.1136/bmj.1.4771.1270.
2
[Chronic interstitial nephritis].
Helv Med Acta. 1950 Oct;17(4-5):564-7.
3
AGRANULOCYTOSIS INDUCED BY DIPYRONE, A HAZARDOUS ANTIPYRETIC AND ANALGESIC.
JAMA. 1964 Sep 21;189:938-41. doi: 10.1001/jama.1964.03070120060014.
4
The use of aminopyrine to control fever in Hodgkin's disease.
JAMA. 1962 Jun 16;180:970-2. doi: 10.1001/jama.1962.03050240066018.
5
Aspirin and gastric haemorrhage.
Lancet. 1959 Mar 14;1(7072):539-41. doi: 10.1016/s0140-6736(59)92308-6.
6
Gastrointestinal haemorrhage and salicylates.
Lancet. 1958 Nov 1;2(7053):920-5. doi: 10.1016/s0140-6736(58)90423-9.
7
Bronchitis, aspirin, smoking, and other factors in the aetiology of peptic ulcer.
Lancet. 1958 Jul 26;2(7039):179-82. doi: 10.1016/s0140-6736(58)91526-5.
8
Value of aminopyrine.
Ann Intern Med. 1958 Mar;48(3):616-34. doi: 10.7326/0003-4819-48-3-616.
9
Salicylates and gastric hemorrhage. II. Manifest bleeding.
Gastroenterology. 1957 Nov;33(5):778-88.
10
The influence of some of the salicyl compounds (and alcoholic beverages) on the natural history of peptic ulcer.
Gastroenterology. 1956 Aug;31(2):198-203.
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