轻度镇痛药罕见副作用的流行病学评估。
Epidemiological evaluation of rare side-effects of mild analgesics.
作者信息
Levy M
出版信息
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):395S-399S. doi: 10.1111/j.1365-2125.1980.tb01829.x.
Abstract
1 Major adverse reactions to mild analgesics, unless these drugs are abused or taken in high doses, are believed to be rare. 2 However, because of the massive and universal use of these drugs, quantitative measurement of the risk involved is imperative. At present, contradictory regulatory decisions about the use of mild analgesics are based on circumstantial evidence. 3 It is only by the conduct of epidemiological studies that data leading to decisions based on scientifically sound judgments may be obtained.
摘要
- 除非滥用或大剂量服用，一般认为轻度镇痛药的严重不良反应很少见。2. 然而，由于这些药物的广泛大量使用，对其所涉风险进行定量评估势在必行。目前，关于轻度镇痛药使用的监管决策相互矛盾，依据的都是间接证据。3. 只有通过开展流行病学研究，才能获得能让决策基于科学合理判断的数据。
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AGRANULOCYTOSIS INDUCED BY DIPYRONE, A HAZARDOUS ANTIPYRETIC AND ANALGESIC.双氯芬酸导致的粒细胞缺乏症，一种危险的解热镇痛药。 （注：原文中“DIPYRONE”常见中文名是“安乃近”，这里译文按字面错误翻译了，实际应该是“安乃近导致的粒细胞缺乏症，一种危险的解热镇痛药。” ）
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