Galili U, Prokocimer M, Izak G
Blood. 1980 Dec;56(6):1077-81.
A marked sensitivity of CLL lymphocytes to hydrocortisone in vitro was demonstrated in each of the 25 patients tested. The sensitivity was manifested by the eventual lysis of the affected cells. Malignant lymphocytes from 8 out of 14 ALL patients were found also to be in vitro sensitive, whereas CML cells, AML cells, normal BM cells, thymocytes, peripheral blood lymphocytes, and polymorphonuclear cells were resistant. Within a tested CLL lymphoid suspension it is proven that the hydrocortisone causes the specific lysis of the malignant cells leaving the normal lymphocytes undamaged. The cytolysis is not an immediate action, but is expressed within 7-8 hr of incubation. However, 30 min incubation with the hormone is sufficient for the cytolytic effect to occur 20 hr later. The possible mechanisms involved in the specific glucocorticoid induced cytolysis are discussed.
在接受检测的25例患者中，每例患者的慢性淋巴细胞白血病（CLL）淋巴细胞在体外均表现出对氢化可的松的显著敏感性。这种敏感性表现为受影响细胞最终发生裂解。在14例急性淋巴细胞白血病（ALL）患者中，有8例患者的恶性淋巴细胞在体外也表现出敏感性，而慢性粒细胞白血病（CML）细胞、急性髓细胞白血病（AML）细胞、正常骨髓细胞、胸腺细胞、外周血淋巴细胞和多形核细胞则具有抗性。在经过检测的CLL淋巴细胞悬液中，已证实氢化可的松可导致恶性细胞发生特异性裂解，而正常淋巴细胞不受损害。细胞溶解并非即时作用，而是在孵育7 - 8小时后才表现出来。然而，与该激素孵育30分钟就足以使其在20小时后产生细胞溶解作用。文中讨论了特异性糖皮质激素诱导细胞溶解可能涉及的机制。
