Rumawas W, Ressang A A
Tijdschr Diergeneeskd. 1980 Oct 15;105(20):234-6.
Anti-bovine lymphocyte serum (ABLS) had been prepared in horses with calf thymocytes as antigen and its effects in calves following parenteral administration were studied. The optimal dose was found to be one ml/kg body weight. The ABLS suppressed both the T and B cell functions. The former was indicated by the disturbed response to sheep erythrocytes infections, by the decreased number of spontaneous E rosette forming lymphocytes, the prolonged survival of skin allografts and the significant inhibition of the delayed hypersensibility skin reaction (tuberculination) following administration of Mycobacterium microti. The latter was based on the disturbed response to a subcutaneous dose of tetanus toxoid. The reaction of lymphocytes of ABLS treated calves to phytohemagglutinin and poke week mitogen was also inhibited. The disturbed reactions of the T and B cells might be among others based on the strong reduction of lymphocytes in the blood circulation by ABLS (up to 10-20%).
以小牛胸腺细胞为抗原，在马体内制备了抗牛淋巴细胞血清（ABLS），并研究了其经肠胃外给药后对小牛的影响。发现最佳剂量为每公斤体重1毫升。ABLS抑制了T细胞和B细胞的功能。前者表现为对绵羊红细胞感染的反应紊乱、自发形成E花环的淋巴细胞数量减少、皮肤同种异体移植存活时间延长以及接种微小分枝杆菌后迟发型超敏皮肤反应（结核菌素反应）受到显著抑制。后者基于对皮下注射破伤风类毒素的反应紊乱。经ABLS处理的小牛淋巴细胞对植物血凝素和商陆有丝分裂原的反应也受到抑制。T细胞和B细胞反应紊乱可能部分是由于ABLS使血液循环中的淋巴细胞数量大幅减少（高达10%-20%）。
