Diethelm A G, Chambers L M, Balch C M, Phillips S J
Postgrad Med J. 1976;52(5 Suppl):55-8.
Anti-human thymocyte cell membrane antibody prepared by hyperimmunization of the horse produced an antiserum capable of prolonging skin allografts in the rhesus monkey for an average of 26 days. Lymphocyte depletion was present in paracortical areas of mesenteric lymph nodes of these animals after 28 days of treatment; the intravenous administration was tolerated without ill effects. Immunofluorescent studies identified both broad specificity antibodies reacting with numerous human cell types as well as thymus-dependent (T) cell antibodies reactive with human thymocytes and peripheral T-cells.
通过马的超免疫制备的抗人胸腺细胞细胞膜抗体产生了一种抗血清，该抗血清能够使恒河猴的同种异体皮肤移植平均延长26天。在治疗28天后，这些动物肠系膜淋巴结的副皮质区出现淋巴细胞耗竭；静脉内给药耐受性良好，无不良影响。免疫荧光研究鉴定出既存在与多种人类细胞类型反应的具有广泛特异性的抗体，也存在与人胸腺细胞和外周T细胞反应的胸腺依赖性（T）细胞抗体。
