阿霉素的免疫抑制及抗炎作用研究。
Studies on immunosuppressive and anti-inflammatory effect of adriamycin.
作者信息
Giełdanowski J, Skowrońska J
出版信息
Arch Immunol Ther Exp (Warsz). 1980;28(3):439-46.
The analysis of immunosuppressive and anti-inflammatory effect of adriamycin in vivo was carried out. Adriamycin restrains blast reaction and decreases the building in of H3 thymidine to the nucleus of lymphocytes. At the same time it decreases the number of B lymphocytes in peripheral blood but it does not influence the level of T lymphocytes. Adriamycin restrains also nonspecific inflammatory reactions reducing the intensity of inflammatory reactions induced by xylene and carrageenin. It also reduces the inflammatory process of granulation. It does not affect histamine and prostaglandin receptors. After discussing the results it was noted that cytostatic effect of adriamycin is accompanied by immunosuppressive and inflammatory components.
对阿霉素在体内的免疫抑制和抗炎作用进行了分析。阿霉素抑制母细胞反应，并减少H3胸腺嘧啶核苷掺入淋巴细胞细胞核。同时，它降低外周血中B淋巴细胞的数量，但不影响T淋巴细胞水平。阿霉素还抑制非特异性炎症反应，降低由二甲苯和角叉菜胶诱导的炎症反应强度。它还减轻肉芽的炎症过程。它不影响组胺和前列腺素受体。在讨论结果后指出，阿霉素的细胞抑制作用伴有免疫抑制和炎症成分。
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