Adler B, Faine S, Muller H K, Green D E
Pathology. 1980 Oct;12(4):529-38. doi: 10.3109/00313028009086806.
Baby guinea-pigs were susceptible to infection with Leptospira interrogans serovar pomona, but rapidly became resistant as they matured. Increased resistance with increasing weight of guinea-pigs was correlated with the development of ability to produce agglutinating antibodies to leptospires and with maturation of B-cell dependent (but not T-cell dependent) areas in lymphoid organs. These observations can explain the basis of species-resistance of adult guinea-pigs to infection with serovar pomona.
幼年豚鼠易感染波摩那群问号钩端螺旋体，但随着它们成熟，会迅速产生抵抗力。豚鼠体重增加，抵抗力增强，这与产生针对钩端螺旋体的凝集抗体的能力发展以及淋巴器官中B细胞依赖区（而非T细胞依赖区）的成熟有关。这些观察结果可以解释成年豚鼠对波摩那群感染具有种属抵抗力的基础。
