一例T细胞慢性淋巴细胞白血病患者的溶酶体酶活性

Lysosomal enzyme activities in a case of T-cell chronic lymphocytic leukaemia.

作者信息

Crockard A D, Morris T C

出版信息

Scand J Haematol. 1980 Sep;25(3):226-30. doi: 10.1111/j.1600-0609.1981.tb01393.x.

DOI:10.1111/j.1600-0609.1981.tb01393.x

Abstract

This study indicated that (i) high levels of N-acetyl-beta-glucosaminidase and beta-glucuronidase could be demonstrated cytochemically in T-CLL lymphocytes, and (ii), the biochemical activities of both enzymes were significantly increased in T-CLL lymphocytes compared with B-CLL lymphocytes. It would appear that the biochemical and cytochemical determination of these lysosomal enzyme activities offers an additional means of distinguishing T-CLL and B-CLL lymphocytes.

摘要

本研究表明

（i）通过细胞化学方法可在T细胞型慢性淋巴细胞白血病（T-CLL）淋巴细胞中检测到高水平的N-乙酰-β-葡萄糖苷酶和β-葡萄糖醛酸酶；（ii）与B细胞型慢性淋巴细胞白血病（B-CLL）淋巴细胞相比，T-CLL淋巴细胞中这两种酶的生化活性显著增加。看来，对这些溶酶体酶活性进行生化和细胞化学测定为区分T-CLL和B-CLL淋巴细胞提供了一种额外的方法。