Kraaijenhagen R J, Schipper-Kester G P, Rijksen G, de Gast G C, Staal G E
Clin Chim Acta. 1982 Feb 5;118(2-3):255-63. doi: 10.1016/0009-8981(82)90012-2.
Eleven lysosomal enzyme activities were tested in lymphocytes from normal individuals and patients with chronic lymphocytic leukemia. The activities of all enzymes, except acid phosphatase, were significantly lower in the leukemic lymphocytes (p less than 0.001). In addition the activities were tested in purified T- and non-T lymphocytes and in monocytes. For most enzymes the activities are similar in the three cell types, except for alpha-D-galactosidase, arylsulphatase B and alpha-D-glucosidase, which are lower in T lymphocytes, and N-acetyl-beta-D-glucosaminidase which is lower in non-T cells. In T and B lymphoblastic cell lines the activities are within the range for leukemic lymphocytes. No differences were found between the T and the B cell lines.
对正常个体及慢性淋巴细胞白血病患者淋巴细胞中的11种溶酶体酶活性进行了检测。除酸性磷酸酶外，白血病淋巴细胞中所有酶的活性均显著降低（p<0.001）。此外，还对纯化的T淋巴细胞、非T淋巴细胞及单核细胞中的酶活性进行了检测。对于大多数酶，三种细胞类型中的活性相似，但α-D-半乳糖苷酶、芳基硫酸酯酶B和α-D-葡萄糖苷酶在T淋巴细胞中的活性较低，N-乙酰-β-D-氨基葡萄糖苷酶在非T细胞中的活性较低。在T和B淋巴母细胞系中，酶活性在白血病淋巴细胞的范围内。T细胞系和B细胞系之间未发现差异。
