生殖器疱疹患者的外周血淋巴细胞亚群

Peripheral lymphocyte subpopulations in patients with herpes genitalis.

作者信息

Ishiguro T, Ozaki Y, Yokoyama M M, Tseng C H, Chao W

出版信息

Immunobiology. 1980 Apr;157(1):24-9. doi: 10.1016/s0171-2985(80)80058-1.

Abstract

Peripheral blood samples from 52 women including 16 with herpes genitalis and 36 healthy persons were studied to enumerate subpopulations of lymphocytes. T lymphocyte counts were done by SRBC rosette tests and B lymphocytes by immunobead rosette tests using antibody-coated polyacrylamide beads. It was found that the mean percentage of "active T lymphocytes was significantly less in the patients with herpes genitalis than in the controls (herpes genitalis; 13.9 +/- 6.8%, controls; 25.0 +/- 8.3%, p less than 0.001). No difference was noted in the percentage of "total" T lymphocytes, "total" B lymphocytes and subsets of B lymphocytes (IgG-, IgA- and IgM-bearing lymphocytes) between the patients and controls. The present findings suggest that cell-mediated immune function associated with "active" T lymphocytes is suppressed in patients with herpes genitalis.

摘要

对52名女性的外周血样本进行了研究，其中包括16名生殖器疱疹患者和36名健康人，以对淋巴细胞亚群进行计数。通过SRBC玫瑰花结试验检测T淋巴细胞计数，使用抗体包被的聚丙烯酰胺珠通过免疫珠玫瑰花结试验检测B淋巴细胞。结果发现，生殖器疱疹患者中“活性”T淋巴细胞的平均百分比显著低于对照组（生殖器疱疹患者；13.9±6.8%，对照组；25.0±8.3%，p<0.001）。患者和对照组之间在“总”T淋巴细胞、“总”B淋巴细胞以及B淋巴细胞亚群（携带IgG、IgA和IgM的淋巴细胞）的百分比方面未发现差异。目前的研究结果表明，生殖器疱疹患者中与“活性”T淋巴细胞相关的细胞介导免疫功能受到抑制。