强直性脊柱炎中的淋巴细胞异常。
Lymphocyte abnormalities in ankylosing spondylitis.
作者信息
Fan P T, Clements P J, Yu D T, Opelz G, Bluestone R
出版信息
Ann Rheum Dis. 1977 Oct;36(5):471-3. doi: 10.1136/ard.36.5.471.
Abstract
Peripheral blood T (SRBC rosette) and B (AgG- and C-receptor) lymphocyte subpopulations and responsiveness to phytohaemagglutinin (PHA) were assayed in 40 patients with ankylosing spondylitis and in 55 normal subjects. There was no significant difference in the lymphocyte concentrations or responsiveness to PHA between the two groups. However, the percentages of T lymphocytes were significantly lower in the patients irrespective of their HLA typing. This was probably due to an increase in the 'null' population since the percentages of both the AgG- and C-receptor cells were normal.
摘要
对40例强直性脊柱炎患者和55名正常受试者检测了外周血T（绵羊红细胞玫瑰花结）和B（AgG及C受体）淋巴细胞亚群以及对植物血凝素（PHA）的反应性。两组之间淋巴细胞浓度或对PHA的反应性无显著差异。然而，无论HLA分型如何，患者的T淋巴细胞百分比均显著降低。这可能是由于“裸细胞”群体增加所致，因为AgG及C受体细胞的百分比均正常。
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