Maradona Hidalgo J A, Arribas Castrillo J M, Rodrigo Sáez L
Med Clin (Barc). 1981 Mar 10;76(5):211-3.
There is no clear explanation for the known fact that peripheral levels of T lymphocytes are decreased in alcoholic hepatic cirrhosis. Cellular immune deficiency in cirrhosis has been attributed to this phenomenon. In order to confirm this observation and clarify its cause, the different lymphocyte populations of the peripheral blood of 52 patients with alcoholic hepatic cirrhosis and of 30 control subjects were studied. Absolute lymphocyte counts were decreased in cirrhotic patients (p less than 0.05) due to a marked reduction of T lymphocytes (p less than 0.001). Furthermore, T lymphocytes and, to a lesser degree, B lymphocytes, but not the remaining lymphocyte populations (referred to as "other lymphocytes" in this study), were decreased in relation to the existence of portal hypertension. Thus, a significant reduction of T and B lymphocytes (p less than 0.001) exists in cirrhotics with portal hypertension with respect to those without portal hypertension. The sequestering action of the hypertrophic spleen in patients with portal hypertension could be responsible for this phenomenon.
酒精性肝硬化患者外周血T淋巴细胞水平降低这一已知事实尚无明确解释。肝硬化中的细胞免疫缺陷归因于此现象。为了证实这一观察结果并阐明其原因，对52例酒精性肝硬化患者和30例对照受试者外周血中的不同淋巴细胞群体进行了研究。肝硬化患者的绝对淋巴细胞计数减少（p<0.05），原因是T淋巴细胞显著减少（p<0.001）。此外，与门静脉高压的存在相关，T淋巴细胞以及程度较轻的B淋巴细胞减少，但其余淋巴细胞群体（本研究中称为“其他淋巴细胞”）未减少。因此，与无门静脉高压的肝硬化患者相比，有门静脉高压的肝硬化患者中T和B淋巴细胞显著减少（p<0.001）。门静脉高压患者肥大脾脏的扣押作用可能是造成这一现象的原因。
