Inbal Rivka, Devor Marshall, Tuchendler Orna, Lieblich Israel
Department of Psychology, The Hebrew University of Jerusalem, Jerusalem Israel Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem Israel.
Pain. 1980 Dec;9(3):327-337. doi: 10.1016/0304-3959(80)90047-0.
Several weeks following transection and ligation of the hind limb nerves in rats, the animals often attack their anaesthetic foot ("autotomy"). This behaviour is thought to reflect a sensory pathology analogous to anaesthesia dolorosa. We report here that the extent of autotomy varies greatly in genetically different populations of rats. Rats of one population, LC2, showed high autotomy levels; rats of another, LC1, showed very low autotomy levels. The main genetic difference between these two populations is the presence of inbred Lewis rat stock in the LC1 population. Pure Lewis strain rats proved to have very low autotomy levels. Thus, constitutional differences between different rat populations effect the extent of autotomy. These data may bear on the fact that after seemingly identical nerve injuries, some humans develop chronic pain syndromes and others do not. Our rat strains may provide a model for investigating the physiological basis of constitutional susceptibility to chronic pain.
在大鼠后肢神经横断和结扎数周后，动物常常攻击其麻醉的足部（“自切”）。这种行为被认为反映了一种类似于痛性麻木的感觉病理学。我们在此报告，自切的程度在基因不同的大鼠群体中差异很大。一个群体LC2的大鼠表现出较高的自切水平；另一个群体LC1的大鼠表现出非常低的自切水平。这两个群体之间的主要基因差异在于LC1群体中存在近交系刘易斯大鼠品系。纯刘易斯品系大鼠被证明自切水平非常低。因此，不同大鼠群体之间的体质差异影响自切的程度。这些数据可能与以下事实有关：在看似相同的神经损伤后，一些人会发展为慢性疼痛综合征，而另一些人则不会。我们的大鼠品系可能为研究体质易感性对慢性疼痛的生理基础提供一个模型。
