Fehr K, Velvart M, Rauber M, Knöpfel M, Baici A, Salgam P, Böni A
Arthritis Rheum. 1981 Mar;24(3):510-9. doi: 10.1002/art.1780240310.
Immunohistochemical studies were performed in synovial tissues from 40 patients with rheumatoid arthritis (RA), 9 with juvenile rheumatoid arthritis (JRA), 7 with psoriatic arthritis, and 4 with various rheumatic diseases. Overall synthesis of IgG- and/or IgM-rheumatoid factor (RF) was found in all patients with seropositive RA and JRA, in 75% of patients with seronegative RA, and in 1 patient with psoriatic arthritis. Agglutinator producing cells were found in 77% of the samples from seropositive RA and in 44% and 56% from seronegative RA and JRA patients, respectively. The percentage of IgG plasma cells synthesizing one or more of the 5 types of agglutinators studied was approximately 10% of plasma cells synthesizing IgG-RF. Intercellular and intracellular immune complex deposits were also found in patients with seropositive and seronegative RA and JRA. These findings suggest that synthesis of agglutinators by synovial tissue plasma cells of RA and JRA patients is a distinct--but definitely less prominent--function than that of RF synthesis.
对40例类风湿性关节炎（RA）患者、9例青少年类风湿性关节炎（JRA）患者、7例银屑病关节炎患者以及4例患有各种风湿性疾病的患者的滑膜组织进行了免疫组织化学研究。在所有血清阳性的RA和JRA患者、75%的血清阴性RA患者以及1例银屑病关节炎患者中均发现了IgG和/或IgM类风湿因子（RF）的总体合成。在血清阳性RA患者的77%的样本中以及分别在血清阴性RA和JRA患者的44%和56%的样本中发现了产生凝集素的细胞。合成所研究的5种凝集素中的一种或多种的IgG浆细胞的百分比约为合成IgG-RF的浆细胞的10%。在血清阳性和血清阴性的RA和JRA患者中也发现了细胞间和细胞内免疫复合物沉积。这些发现表明，RA和JRA患者滑膜组织浆细胞合成凝集素是一种与RF合成不同的功能——但肯定不那么突出。
