Artmann G, Fehr K, Boni A
Arthritis Rheum. 1977 Jun;20(5):1105-13. doi: 10.1002/art.1780200510.
The incidence and titer of cathepsin D agglutinators (CDA) were significantly higher in seropositive rheumatoid arthritis (RA) sera than in the sera of healthy blood donors or of patients with other rheumatic diseases, including seronegative RA. A significant elevation was also found in synovial fluid (SF) samples from seropositive RA patients. CDA in the SF tended to be increased when compared with the corresponding serum. The levels of CDA correlated positively with those of rheumatoid factors (RF) when the latter were determined with IgG anti-CD Ripley-coated erythrocytes, but not when they were determined by the Waaler-Rose or latex tests. The increased CDA titers do not seem to be the result of significant amounts of IgM agglutinators or of the presence of IgM-RF. These findings suggest the existence of a link between the formation of RF and CDA, but the nature of this link cannot be fully explained.
在血清阳性的类风湿关节炎（RA）患者血清中，组织蛋白酶D凝集素（CDA）的发生率和滴度显著高于健康献血者或其他风湿性疾病患者（包括血清阴性RA患者）的血清。在血清阳性RA患者的滑膜液（SF）样本中也发现了显著升高。与相应血清相比，SF中的CDA往往会增加。当用IgG抗CD Ripley包被的红细胞检测类风湿因子（RF）时，CDA水平与RF水平呈正相关，但用瓦勒-罗斯试验或乳胶试验检测时则不然。CDA滴度升高似乎不是大量IgM凝集素或IgM-RF存在的结果。这些发现表明RF和CDA的形成之间存在联系，但这种联系的性质尚不能完全解释。
