关于噻洛芬酸的药代动力学及其与乙酰水杨酸和氢氧化铝可能的相互作用（作者译）
[On the pharmacokinetics of tiaprofenic acid and its possible interactions with acetylsalicylic acid and aluminum hydroxide (author's transl)].
作者信息
Marećek N, Lücker P W, Penth B, Altmayer P, Wetzelsberger K
出版信息
Arzneimittelforschung. 1981;31(1):116-20.
PMID:6971108
Abstract
To clarify the question whether pharmacokinetic properties of tiaprofenic acid (presumable trade name Surgam) can be changed by simultaneous application of aluminum hydroxide or acetylsalicylic acid (ASA) a randomized study of 7 healthy volunteers was carried out. The results show that the bioavailability as well as the pharmacokinetic profile of orally administered tiaprofenic acid is not changed by the mentioned compounds.
摘要
为了明确同时应用氢氧化铝或乙酰水杨酸（ASA）是否会改变噻洛芬酸（可能的商品名Surgam）的药代动力学特性，对7名健康志愿者进行了一项随机研究。结果表明，口服噻洛芬酸的生物利用度以及药代动力学特征不会因上述化合物而改变。
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