Hokland P, Hokland M, Ellegaard J
Blood. 1981 May;57(5):972-4.
This is the first report describing natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) of malignant monoblasts. Pure acute monoblastic leukemia was diagnosed in bone marrow aspirations from two patients by use of conventional cytochemical methods as well as multiple immunologic techniques including detection of ALL antigens and terminal transferase. The malignant cells were subsequently found to be potent effectors in NK and ADCC assays. Addition of partially purified alpha-interferon to the in vitro cultures was found to have an enhancing effect on NK activity, whereas no modulation was seen in ADCC. These findings are discussed in the light of our present knowledge of lymphoid NK cells.
这是首篇描述恶性成单核细胞自然杀伤（NK）及抗体依赖细胞介导的细胞毒性（ADCC）的报告。运用传统细胞化学方法以及包括检测ALL抗原和末端转移酶在内的多种免疫学技术，在两名患者的骨髓穿刺样本中诊断出了纯急性单核细胞白血病。随后发现这些恶性细胞在NK和ADCC检测中是有效的效应细胞。向体外培养物中添加部分纯化的α干扰素被发现对NK活性有增强作用，而在ADCC中未观察到调节作用。根据我们目前对淋巴样NK细胞的了解对这些发现进行了讨论。
