Numata M, Mitsuboshi Y, Nitta K
Cancer Res. 1981 Apr;41(4):1492-6.
A B-lymphocyte tumor (MLB-MN line) was induced by Gross murine leukemia virus in Slc:ddY mice, successively passaged in normal adult mice, and adapted to tissue culture. The surface marker expression of MLB-MN was examined and found to include several markers that are known to occur in normal B-lymphocytes. The cells bore surface immunoglobulin M, detected by indirect immunofluorescence staining, and Fc receptors and complement receptors, detected by rosette formation. Thy 1 antigen and secretion of immunoglobulin were lacking. These results have led us to postulate that the origin of the MLB-MN tumor was a late differentiation stage of the B-lymphocyte.
格罗斯小鼠白血病病毒在Slc:ddY小鼠中诱发了一种B淋巴细胞肿瘤（MLB-MN系），该肿瘤在正常成年小鼠中连续传代，并适应了组织培养。对MLB-MN的表面标志物表达进行了检测，发现其包括几种已知在正常B淋巴细胞中出现的标志物。通过间接免疫荧光染色检测到细胞带有表面免疫球蛋白M，通过玫瑰花结形成检测到Fc受体和补体受体。缺乏Thy 1抗原和免疫球蛋白分泌。这些结果使我们推测MLB-MN肿瘤的起源是B淋巴细胞的晚期分化阶段。
