来自多发性硬化症血清的一种因子对分离出的T淋巴细胞和B淋巴细胞的作用。
The effect of a factor from multiple sclerosis serum on isolated T and B lymphocytes.
作者信息
Armentrout S A, Sweet P M, Galant S P
出版信息
J Clin Lab Immunol. 1981 May;5(3):133-6.
PMID:6972451
Abstract
Lymphocyte transformation inhibition factor (LTIF) found in the serum of patients with active multiple sclerosis (MS) inhibits the mitogen-induced blast transformation of human lymphocytes. The results of these experiments demonstrate the relative specificity for the T lymphocyte by LTIF. The inhibitory effect of patient's serum on normal mitogen-stimulated lymphocytes was correlated with the level of clinical disease activity.
摘要
在活动性多发性硬化症（MS）患者血清中发现的淋巴细胞转化抑制因子（LTIF）可抑制有丝分裂原诱导的人淋巴细胞的母细胞转化。这些实验结果证明了LTIF对T淋巴细胞具有相对特异性。患者血清对正常有丝分裂原刺激的淋巴细胞的抑制作用与临床疾病活动水平相关。
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