巨细胞动脉炎患者的免疫复合物、类风湿因子及细胞免疫学参数
Immune complexes, rheumatoid factors, and cellular immunological parameters in patients with giant cell arteritis.
作者信息
Malmvall B E, Bengtsson B A, Nilsson L A, Bjursten L M
出版信息
Ann Rheum Dis. 1981 Jun;40(3):276-80. doi: 10.1136/ard.40.3.276.
Circulating immune complexes were found in 2 of 15 patients with giant cell arteritis (GCA) by using a solid phase Clq enzyme linked immunoabsorbent assay (ELISA). The prevalence in controls was 5%. Rheumatoid factor could be demonstrated in 2 out of 27 patients and in 11% of the controls by using a similar ELISA technique. The prevalence of T cells in blood was similar in 25 patients with GCA and in controls. The blood lymphocyte blastogenic response to the mitogens, phytohaemagglutinin, concanavalin-A, and pokeweed mitogen did not differ in 25 untreated patients compared with controls. Stimulation of lymphocytes by arterial homogenates was tested in 8 patients. In no case could a significant simulation by obtained. We conclude that immune complexes and rheumatoid factors are present in the same low frequency in GCA patients as in the normal population, and that the studied parameters of cellular immunity appear to be normal.
通过使用固相Clq酶联免疫吸附测定法（ELISA），在15例巨细胞动脉炎（GCA）患者中的2例发现了循环免疫复合物。对照组中的患病率为5%。通过使用类似的ELISA技术，在27例患者中的2例以及11%的对照组中检测到类风湿因子。25例GCA患者血液中T细胞的患病率与对照组相似。25例未经治疗的患者与对照组相比，对有丝分裂原植物血凝素、刀豆球蛋白A和商陆有丝分裂原的血液淋巴细胞增殖反应没有差异。对8例患者进行了动脉匀浆刺激淋巴细胞的测试。在任何情况下都未获得显著的刺激效果。我们得出结论，GCA患者中免疫复合物和类风湿因子的出现频率与正常人群相同，且所研究的细胞免疫参数似乎正常。
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