用放线菌素对小鼠红斑狼疮进行晚期治疗。II. C1和抗DNA抗体。
Late treatment of murine lupus erythematosus with dactinomycin. II. C1 and antibody to DNA.
作者信息
Olsen C T, Teague P O, Gabrielsen A E
出版信息
Immunology. 1981 Jun;43(2):213-7.
Abstract
(NZB x NZW)F1 hybrid (B/W) female mice were treated intermittently with dactinomycin beginning at 6--6.5 months of age. Survival was greatly prolonged relative to control mice. IgG antibody to DNA did not decline significantly in the treated mice until they were more than 18 months old, but circulating levels of the first complement component (Cl) rose during the first 4 weeks of treatment and were back into the normal range after 8 weeks. Thus these two humoral indexes of disease activity varied independently, and only Cl reflected the improved status of the treated mice.
摘要
（新西兰黑鼠×新西兰白鼠）F1杂交（B/W）雌性小鼠在6至6.5月龄时开始间断给予放线菌素治疗。与对照小鼠相比，其生存期显著延长。治疗组小鼠中抗DNA的IgG抗体直到18个月龄后才显著下降，但在治疗的前4周，第一补体成分（C1）的循环水平升高，8周后恢复到正常范围。因此，这两个疾病活动的体液指标变化相互独立，只有C1反映了治疗组小鼠状况的改善。
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本文引用的文献
1
DNA-binding assay for detection of anti-DNA antibodies in NZB-NZW F1 mice.用于检测NZB-NZW F1小鼠中抗DNA抗体的DNA结合试验。
J Immunol. 1969 Mar;102(3):788-90.
2
Complement-dependent alterations in the handling of immune complexes by NZB/W mice.NZB/W小鼠对免疫复合物处理过程中补体依赖性改变
J Immunol. 1975 Apr;114(4):1166-70.
3
Early complement components in NZB/NZW mice. I. The first component.NZB/NZW小鼠中的早期补体成分。I. 第一成分。
J Immunol. 1979 Jan;122(1):133-5.
4
Stimulated autoantibody response and increased longevity in NZB/NZW mice treated with cyclophosphamide and tilorone.用环磷酰胺和泰洛龙治疗的NZB/NZW小鼠的自身抗体反应增强及寿命延长。
Clin Exp Immunol. 1978 Sep;33(3):453-62.
5
Delayed androgen treatment prolongs survival in murine lupus.延迟雄激素治疗可延长小鼠狼疮的生存期。
J Clin Invest. 1979 May;63(5):902-11. doi: 10.1172/JCI109390.
6
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Clin Exp Immunol. 1979 Jan;35(1):33-5.
7
Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.自发性小鼠狼疮样综合征。几种品系的临床和免疫病理学表现。
J Exp Med. 1978 Nov 1;148(5):1198-215. doi: 10.1084/jem.148.5.1198.
8
Prostaglandin E treatment of NZB/NZW mice.前列腺素E对NZB/NZW小鼠的治疗
Arthritis Rheum. 1977 Mar;20(2):723-8. doi: 10.1002/art.1780200213.
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Thiamphenicol and lupus nephritis. The effects of long-term therapy on kidney function and pathology: a pilot study.甲砜霉素与狼疮性肾炎。长期治疗对肾功能及病理的影响：一项初步研究。
Br J Exp Pathol. 1979 Feb;60(1):45-57.
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Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique.DNA的免疫学。III. 绿蝇短膜虫，一种用免疫荧光技术检测抗双链DNA的简单底物。
Ann N Y Acad Sci. 1975 Jun 30;254:505-15. doi: 10.1111/j.1749-6632.1975.tb29197.x.
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